Studies on Mesoionic Compounds. II. Synthesis of N-Acyl Derivatives of 3-Dialkylaminosydnonimines
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概要
- 論文の詳細を見る
A number of N-acyl and N-nitroso-3-dialkylaminosydnonimines (II) were synthesized by various acylating methods. In some cases, the acylation with activated esters, mixed anhydrides or dicyclohexylcarbodiimide was found to be more favorable. The reactivities of these derivatives towards acids and alkalis were investigated. Trifluoroacetyl (II-6) and formyl (II-1) compounds were easily deacylated in varuous conditions. Methylation took place at the acylated imino nitrogen of N-ethoxycarbonyl compound to give the quaternary salt (II-18). N-Acetyl compound (II-2) was compared with its 3-alkyl analog in the physicochemical properties ; its pK_a values reveals that the morpholino group has little effect on the basicity of the compound.
- 社団法人日本薬学会の論文
- 1971-01-25
著者
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増田 克忠
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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増田 克忠
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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金児 龍彦
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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神谷 高明
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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今城 芳夫
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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神谷 高明
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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金児 龍彦
Research and Development Division, Takeda Chemical Industries, Ltd.,
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今城 芳夫
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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金児 龍彦
Research And Development Division Takeda Chemical Industries Ltd.
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