Synthesis of Tricholomic Acid. IV. Synthesis of DL-threo-α-Amino-3-oxo-5-isoxazolidineacetic Acid

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概要

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• DL-threo-α-Amino-3-oxo-5-isoxazolidineacetic acid, an isomer of tricholomic acid, was synthesized in a 3-step sequence starting from dialkyl N-acyl-β-chloroglutamate. Several isolations have been attempted to separate the threo- and erythro-isomers from their mixture. The threo-isomer was devoid of good taste and flycidal activity which are characteristic of the erythro-isomer.

• 公益社団法人日本薬学会の論文
• 1969-05-25

著者

• 畑中 千年

  Chemical Research Laboratories, Research and Developmemt Division, Takeda Chemical Industries, Ltd.

• 神谷 高明

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 岩崎 英介

  Chemical Research Laboratories and Microbiological Research Laboratories, Central Research Division,

• 畑中 千年

  Research and Development Division, Takeda Chemical Industries, Ltd

• 上柳 次三郎

  Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 岩崎 英介

  Chemical Research Laboratories And Microbiological Research Laboratories Central Research Division T

• 神谷 高明

  Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

• 上柳 次三郎

  Microbiological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 畑中 千年

  Research And Development Division Takeda Chemical Industries Ltd

• 砂田 裕

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 上柳 次三郎

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 砂田 裕

  Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

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