Synthesis of Peptides related to Corticotropin (ACTH). IX. Application of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Ester Procedure to the Synthesis of Human Adrenocorticotropic Hormone (α_h-ACTH)
スポンサーリンク
概要
- 論文の詳細を見る
Human adrenocorticotropic hormone (α_h-ACTH), H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH, was synthesized by using N-hydroxy-5-norbornene-2,3-dicarboximide (HONB) with N, N'-dicyelohexylcarbodiimide (DCC) for the stepwise elongation and fragment condensation. The synthetic α_h-ACTH, purified on a column of carboxymethylcellulose, Amberlite XAD-2 resin and Bio-Gel P-6,was found to be homogeneous by various criteria and exhibits full biological activity (ca. 145 units/mg) in in vitro steroidogenic assay.
- 社団法人日本薬学会の論文
- 1975-06-25
著者
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西村 紀
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品中央研
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西村 紀
Medical Research Laboratory, Takeda Chemical Ind. Ltd.
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藤野 政彦
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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畑中 千年
Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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畑中 千年
Research and Development Division, Takeda Chemical Industries, Ltd
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畑中 千年
Research And Development Division Takeda Chemical Industries Ltd
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