Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine

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概要

• 論文の詳細を見る

• Various multi-substituted benzenesulfonyl protecting groups for the guanidino function of arginine, removable under mild conditions such as with trifluoroacetic acid (TFA)-thioanisole, were studied. Among them, the 4-methoxy-2,6-dimethylbenzenesulfonyl (Mds) group, the 2,3,4,5,6-pentamethylbenzenesulfonyl (Pme) group, and the 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group were found to be useful. Both Mds and Pme show considerable resistance to TFA and, therefore, are suitable for procedures in which the intermediates are deprotected by TFA treatment, while Mtr is the most useful protecting group when TFA treatment is not necessary.

• 社団法人日本薬学会の論文
• 1981-10-25

著者

• 藤野 政彦

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品工業

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品中央研

• 北田 千恵子

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 藤野 政彦

  武田薬品工業(株)

• 北田 千恵子

  Discovery Research Division Takeda Chemical Industries Ltd.

• Kitada Chieko

  Discovery Research Division Takeda Chemical Industries Ltd

• 脇舛 光廣

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 脇舛 光廣

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

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