Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis.IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RH/FSH-RH)
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概要
- 論文の詳細を見る
Gonadotropin-releasing hormone (Gn-RH or LH-RH/FSH-RH), a decapeptide amide (Pyr) Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH_2,was synthesized by the use of the d-isobornyloxycarbonyl-protercting group for temporary protection of the all amino groups of the intermediary peptides. The synthetic Gn-RH possessed full biological activity (LH-releasing and FSH-releasing activity) when compared with natural highly purified porcine Gn-RH, and appeared to be pure by various chemical criteria.
- 社団法人日本薬学会の論文
- 1973-01-25
著者
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藤野 政彦
武田薬品工業
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藤野 政彦
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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福田 常彦
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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大林 幹彦
Central Research Division, Takeda Chemical Industries, Ltd.
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大林 幹彦
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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大林 幹彦
Central Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品中央研
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小林 栄
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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小林 栄
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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