リュープリン (高活性LH-RH誘導体) の研究開発

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概要

• 論文の詳細を見る

• Biologically active peptide have potential therapeutic applications in the treatment of diseases caused by peptide deficiency. However, there are only a few peptide drugs, Elcitonin (a calcitonin derivatives for osteoporosis, Asahikasei), Hirutonin (TRH tartrate for prolonged disturbance of consciousness, Takeda) and Leuplin (a highly potent LH-RH derivative for prostate cancer/endometriosis, Takeda) There are two serious drawbacks to using peptide derivatives as drugs : their poor oral bioavailability and their short duration of activity. Although the latter can be overcome by studing various derivatives, the development of orally active peptide derivatives is almost impossible. I would like to describe briefly the process of the research and development of “Leuplin Depot”, once-a-month depot type formulation of super agonist of LH-RH.

• 社団法人 有機合成化学協会の論文

著者

• 藤野 政彦

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品工業

• 藤野 政彦

  武田薬品中央研

• 藤野 政彦

  武田薬品工業(株)

• 藤野 政彦

  武田薬品工業株式会社創薬研究本部

関連論文

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