最近の生理活性ペプチド研究--立体構造と作用機作を中心に (アミノ酸・核酸<特集>)
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概要
著者
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藤野 政彦
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品工業
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藤野 政彦
武田薬品中央研
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藤野 政彦
武田薬品工業(株)
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北田 千恵子
Discovery Research Division Takeda Chemical Industries Ltd.
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Kitada Chieko
Discovery Research Division Takeda Chemical Industries Ltd
関連論文
- 医薬品としてのペプチドおよびタンパク質 (タンパク質化学の新展開)
- Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
- Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis
- The Synthesis of Serum Thymic Factor and Its Analogs
- Synthesis and Pharmacology of TRH Analogs to separate Central Nervous Action from Endocrine Activity
- Synthesis of Salmon Endorphin
- Studies on Peptides. LXXX. N^G-Mesitylene-2-sulfonylarginine
- New Method for Removing the S-p-Methoxybenzyl and S-t-Butyl Groups of Cysteine Residues with Mercuric Trifluoroacetate
- Studies on Peptides. LX. Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Bovine Adrenocorticotropic Hormone
- p-Methoxybenzenesulfonyl as a Protecting Group of Guanidino Function in Peptide Synthesis
- Synthesis of Peptides related to Corticotropin (ACTH). IX. Application of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Ester Procedure to the Synthesis of Human Adrenocorticotropic Hormone (α_h-ACTH)
- Synthesis of Peptides related to Corticotropin (ACTH). VIII. Synthesis of α^-ACTH
- The Use of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Esters in Peptide Synthesis
- Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis. I. Synthesis and Properties of Isobornyloxycarbonylamino Acids
- Synthesis of Peptides related to Corticotropin (ACTH). VII. Syntheses and Biological Activity of Leucine^7-α^-ACTH and N^α-Methyltryptophan^9-α^-ACTH
- Synthesis of Peptides Related to Corticotropin (ACTH). VI. Syntheses and Biological Activity of the Peptides Corresponding to the Amino Acid Sequences 4-23,5-23,6-24 and 7-23 in ACTH
- Synthesis of Peptides related to Corticotropin (ACTH). V. Syntheses of Leucine^4- and Isoleucine^4-α^-ACTH
- Synthesis of Peptides related to Corticotropin (ACTH). IV. Syntheses of β-Alanine^1-, γ-Aminobutyric Acid^1-, Sarcosine^1-, Proline^1- and Lysine^1-α^-ACTH
- Synthesis of Peptides related to Corticotropin (ACTH). III. Syntheses of α^_2-ACTH and β-Alanine^1-α^_2-ACTH
- 蛋白およびペプチド性医薬品の開発における諸問題
- LOCALIZATION OF PROLACTIN - RELEASING PEPTIDE (PrRP) IN THE RAT BRAIN ; ESPECIALLY IN RELATION TO OXYTOCIN NEURONS
- Synthesis of Some Di-and Tri-Substituted Analogs of Luteinizing Hormone Releasing Hormone (LH-RH)
- Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis.IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RH/FSH-RH)
- DETECTION OF THE NEW APPEARANCE OF PROLACTIN-RELEASING PEPTIDE (PrRP)-PRODUCING CELLS IN THE AREA POSTREMA OF THE RAT MEDULLA OBLONGATA
- Synthesis and Biological Activity of 8-L-Ala-Motilin and 8-D-Ala-Motilin
- Application of an Automated Synthesis Suite to Parallel Solution-Phase Peptide Synthesis
- Solution-Phase Automated Synthesis of Tripeptide Derivatives
- Novel LH-RH Receptor Antagonists ; Design, Synthesis, and Antagonistic Activities of Cyclic Pentapeptides
- Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities
- A New Mast Cell Degranulating Peptide "Mastoparan" in the Venom of Vespula lewisii
- Synthesis of the Dodecapeptide Amide corresponding to the Entire Amino Acid Sequence of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
- Synthesis of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
- A Solution-Phase Synthesis of Fragment Peptide Derivatives Using an Automated Synthesis Apparatus
- Application of a Unique Automated Synthesis System for Solution-phase Peptide Synthesis
- 最近の生理活性ペプチド研究--立体構造と作用機作を中心に (アミノ酸・核酸)
- 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) : a New Amino and Imidazole Protecting Group in Peptide Synthesis
- Synthesis of the Heptadecapeptide corresponding to the Full Sequence of Dynorphin
- Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine
- Use of the 4-Methoxy-2,6-dimethylbenzenesulfonyl (Mds) Group to Synthesize Dynorphin [1-13] and Related Peptides
- 29 担子菌酵母,Tremella mesentericaの接合管形成誘導物質
- 1B-12 Saccharomyces kluyveriの性フェロモン, 特にSaccharomyces cerevisiaeの性フェロモンとの関連性
- 生理活性ペプチドの合成--構造-活性相関を中心として (アミノ酸・核酸特集)
- Synthesis of the Carboxy Terminal Fragments of the β-Subunit of the Human Chorionic Gonadotropin(hCG)
- 1 Tremella mesenterica の接合管誘導物質,tremerogen A-10の化学構造と,合成類縁体の生物活性
- New Peptide Models for Studying Racemization
- Synthesis of the Nonacosapeptide corresponding to Mammalian Glucagon
- Synthesis of Porcine Motilin and Its D-Phe^1-Analog by the Use of Methanesulfonic Acid
- High Potency Analogs of Apelin, A Ligand of Orphan GPCR APJ
- GALP, a Novel Galanin-like Peptide Found in Porcine Hypothalamus : Isolation and cDNA Cloning
- Synthesis of New Peptides with Prolactin-releasing Activity by a Combination of Recombinant DNA Technology and a Cysteine-specific Cyanylation Reaction
- Identification of Prolactin-Releasing Peptide
- Synthesis of New Peptides with Prolactin-releasing Activity by a Combination of Recombinant DNA Technology and a Cysteine-specific Cyanylation Reaction
- IDENTIFICATION OF A CORTISTATIN-LIKE PEPTIDE IN HUMAN
- Determination of Disulfide Bonds in Recombinant EG-VEGF/Prokineticin 1
- 新しい天然生理活性物質の研究--天然由来ペプチド研究の動向(総説シリ-ズ--現代医学の焦点-46-)
- New Protecting Groups for the Indole Ring of Tryptophan in Peptide Synthesis : 2,4,6-Trimethoxybenzenesulfonyl and 4-Methoxy-2,3,6-trimethylbenzenesulfonyl Groups
- Synthesis of immunologically Active Muramyl Dipeptide Derivatives containing a Quinonyl Moiety via Aminoacyl Intermediates
- Muramyl Dipeptide(MDP)誘導体の合成と免疫アジュバント活性
- Novel Quinonyl Derivatives of Muramyl Dipeptide Possessing Potent Antitumor Activity
- Synthesis of the Nonatetracontapeptide corresponding to the Sequence proposed for Thymopoietin II
- 創薬科学賞受賞 インスリン抵抗性改善薬ピオグリタゾンの創製
- MCHレセプターおよびそのアンタゴニスト (特集 肥満症の分子メカニズム--アディポサイエンス最前線)
- ゲノム情報を活用した21世紀の創薬
- 創薬技術はどこまで進むか (21世紀の医療と創薬--これからの医療・薬物療法はどう変わるか) -- (第2章 21世紀の創薬と薬物療法)
- 薬のディスカバリーはどのように行われるか (特集 新しい医薬品をどう創り,どう評価するか)
- 21世紀の創薬
- 画期的な新薬の研究開発(新薬開発体制における戦略的展開)
- 技術賞受賞アンジオテンシンII受容体拮抗薬カンデサルタンシレキセチルの創製
- ゲノム研究と創薬の可能性(ゲノム科学と医療)
- 遺伝子研究と創薬
- 技術賞受賞トロンボキサンA_2受容体拮抗薬セラトロダストの創製研究
- 第17回ペプチド化学討論会
- 新規オーファン受容体のリガンド-プロラクチン放出ペプチド(PrRP)の発見-
- エンドセリン遺伝子のクロ-ニング
- 第18回ペプチド化学討論会
- Synthesis of a Wasp Venom Tetradecapeptide, Mastoparan, with a New Cleaving System for 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) Amino-Protecting Group
- リュープリン(LH-RH super-agonist)の研究開発 (最先端創薬--戦略的アプローチと先端的医薬品) -- (先端的医薬品--単一成分に対するアプローチ)
- リュ-プリン(高活性LH-RH誘導体)の研究開発 (生命科学を指向したペプチド合成の進歩)
- ペプチドから非ペプチドへ
- ポストゲノム時代を迎えた医薬品研究開発
- オーファン受容体のリガンド探索とゲノム創薬 (特集 薬理ゲノミックスとゲノム創薬戦略--日本薬学会第120年会より)
- Synthetic Studies on Enkephalin Analogs. III. A Highly Potent Enkephalin Analog, H-Tyr-D-Met (O)-Gly-Phe-NHNH-CO-CH_2CH_3
- 胸腺ペプチドの合成と免疫活性
- Synthesis of the Nonacosapeptide corresponding to the Proposed Amino Acid Sequence of Turkey Glucagon
- Structure-Taste Relationships of L-Aspartyl-Aminomalonic Acid Diesters
- リュープリン (高活性LH-RH誘導体) の研究開発
- Muramyl Dipeptide (MDP) 誘導体の合成と免疫アジュバント活性
- ペプチドの医薬品への応用 (アミノ酸・核酸特集)
- 生理活性ペプチドの合成
- ゲノム創薬の展望
- 創薬の移り変わり