New Method for Removing the S-p-Methoxybenzyl and S-t-Butyl Groups of Cysteine Residues with Mercuric Trifluoroacetate

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概要

• 論文の詳細を見る

• The S-p-methoxybenzyl, S-t-butyl and S-1-adamantyl groups of cysteine were smoothly cleaved with mercuric acetate in trifluoroacetic acid or mercuric trifluoroacetate in aqueous acetic acid. The treatment of the formed mercaptides with thiols regenerated cysteine derivatives. This new method was applied to the synthesis of biologically active polypeptides oxytocin and somatostatin.

• 社団法人日本薬学会の論文
• 1978-05-25

著者

• 西村 紀

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品工業

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品中央研

• 北田 千恵子

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 北田 千恵子

  Discovery Research Division Takeda Chemical Industries Ltd.

• Kitada Chieko

  Discovery Research Division Takeda Chemical Industries Ltd

関連論文

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• Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis
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