Synthesis of the Nonacosapeptide corresponding to the Proposed Amino Acid Sequence of Turkey Glucagon
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概要
- 論文の詳細を見る
The nonacosapeptide corresponding to the proposed amino acid sequence of turkey glucagon was synthesized via the corresponding sulfoxide, [Met (O)^<27>]-turkey glucagon. For the synthesis of the protected nonacosapeptide six peptide fragments were prepared and the condensations of the fragments were achieved by the HONB-DCC method. Finally, all the protecting groups were removed by the treatment with anhydrous hydrogen fluoride-anisole to give [Met (O)^<27>]-turkey glucagon. The sulfoxide was then treated with aqueous thioglycolic acid to give turkey glucagon, which was successfully crystallized from dilute aqueous sodium chloride solution. The biological activity, lipolysis on rat adipocytes, of the synthetic turkey glucagon was as potent as that of mammalian glucagon.
- 1978-05-25
著者
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藤野 政彦
武田薬品工業
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藤野 政彦
武田薬品中央研
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脇舛 光広
Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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脇舛 光広
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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