Synthesis of a Wasp Venom Tetradecapeptide, Mastoparan, with a New Cleaving System for 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) Amino-Protecting Group

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概要

• 論文の詳細を見る

• The 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group was introduced for protection of the ε-amino function of lysine and its acid lability was examined. The cleavage of Lys (Mtr) was accelerated by addition of methyl sulfide, as a second scavenger, to methanesulfonic acidcontaining trifluoroacetic acid-thioanisole. In order to examine the usefulness of the new cleaving system with methyl sulfide, a wasp venom peptide, mastoparan, was synthesized. This system was found to give a highly pure product in good yield.

• 公益社団法人日本薬学会の論文
• 1984-06-25

著者

• 藤野 政彦

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品工業

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 斎藤 一樹

  東京大学 理

• 藤野 政彦

  武田薬品中央研

• 藤野 政彦

  武田薬品工業(株)

• 齋藤 一樹

  Department Of Biophysics And Biochemistry Faculty Of Science University Of Tokyo

• 脇舛 光広

  Chemistry Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 東島 勉

  Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo

• 宮澤 辰雄

  Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo

• 脇舛 光広

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 宮澤 辰雄

  Department Of Biophysics And Biochemistry Faculty Of Science University Of Tokyo

• 東島 勉

  Department Of Biophysics And Biochemistry Faculty Of Science University Of Tokyo

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