Muramyl Dipeptide(MDP)誘導体の合成と免疫アジュバント活性

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概要

• 論文の詳細を見る
• 有機合成化学協会の論文

著者

• 藤野 政彦

  武田薬品中央研

関連論文

• 医薬品としてのペプチドおよびタンパク質 (タンパク質化学の新展開)
• Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
• Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis
• The Synthesis of Serum Thymic Factor and Its Analogs
• Synthesis and Pharmacology of TRH Analogs to separate Central Nervous Action from Endocrine Activity
• Synthesis of Salmon Endorphin
• Studies on Peptides. LXXX. N^G-Mesitylene-2-sulfonylarginine
• New Method for Removing the S-p-Methoxybenzyl and S-t-Butyl Groups of Cysteine Residues with Mercuric Trifluoroacetate
• Studies on Peptides. LX. Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Bovine Adrenocorticotropic Hormone
• p-Methoxybenzenesulfonyl as a Protecting Group of Guanidino Function in Peptide Synthesis
• Synthesis of Peptides related to Corticotropin (ACTH). IX. Application of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Ester Procedure to the Synthesis of Human Adrenocorticotropic Hormone (α_h-ACTH)
• Synthesis of Peptides related to Corticotropin (ACTH). VIII. Synthesis of α^-ACTH
• The Use of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Esters in Peptide Synthesis
• Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis. I. Synthesis and Properties of Isobornyloxycarbonylamino Acids
• Synthesis of Peptides related to Corticotropin (ACTH). VII. Syntheses and Biological Activity of Leucine^7-α^-ACTH and N^α-Methyltryptophan^9-α^-ACTH
• Synthesis of Peptides Related to Corticotropin (ACTH). VI. Syntheses and Biological Activity of the Peptides Corresponding to the Amino Acid Sequences 4-23,5-23,6-24 and 7-23 in ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). V. Syntheses of Leucine^4- and Isoleucine^4-α^-ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). IV. Syntheses of β-Alanine^1-, γ-Aminobutyric Acid^1-, Sarcosine^1-, Proline^1- and Lysine^1-α^-ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). III. Syntheses of α^_2-ACTH and β-Alanine^1-α^_2-ACTH
• Synthesis of Some Di-and Tri-Substituted Analogs of Luteinizing Hormone Releasing Hormone (LH-RH)
• Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis.IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RH/FSH-RH)
• Synthesis and Biological Activity of 8-L-Ala-Motilin and 8-D-Ala-Motilin
• Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities
• A New Mast Cell Degranulating Peptide "Mastoparan" in the Venom of Vespula lewisii
• Synthesis of the Dodecapeptide Amide corresponding to the Entire Amino Acid Sequence of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
• Synthesis of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
• Application of a Unique Automated Synthesis System for Solution-phase Peptide Synthesis
• 最近の生理活性ペプチド研究--立体構造と作用機作を中心に (アミノ酸・核酸)
• 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) : a New Amino and Imidazole Protecting Group in Peptide Synthesis
• Synthesis of the Heptadecapeptide corresponding to the Full Sequence of Dynorphin
• Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine
• Use of the 4-Methoxy-2,6-dimethylbenzenesulfonyl (Mds) Group to Synthesize Dynorphin [1-13] and Related Peptides
• 29 担子菌酵母,Tremella mesentericaの接合管形成誘導物質
• 1B-12 Saccharomyces kluyveriの性フェロモン, 特にSaccharomyces cerevisiaeの性フェロモンとの関連性
• 生理活性ペプチドの合成--構造-活性相関を中心として (アミノ酸・核酸特集)
• Synthesis of the Carboxy Terminal Fragments of the β-Subunit of the Human Chorionic Gonadotropin(hCG)
• 1 Tremella mesenterica の接合管誘導物質,tremerogen A-10の化学構造と,合成類縁体の生物活性
• New Peptide Models for Studying Racemization
• Synthesis of the Nonacosapeptide corresponding to Mammalian Glucagon
• Synthesis of Porcine Motilin and Its D-Phe^1-Analog by the Use of Methanesulfonic Acid
• 新しい天然生理活性物質の研究--天然由来ペプチド研究の動向(総説シリ-ズ--現代医学の焦点-46-)
• New Protecting Groups for the Indole Ring of Tryptophan in Peptide Synthesis : 2,4,6-Trimethoxybenzenesulfonyl and 4-Methoxy-2,3,6-trimethylbenzenesulfonyl Groups
• Synthesis of immunologically Active Muramyl Dipeptide Derivatives containing a Quinonyl Moiety via Aminoacyl Intermediates
• Muramyl Dipeptide(MDP)誘導体の合成と免疫アジュバント活性
• Novel Quinonyl Derivatives of Muramyl Dipeptide Possessing Potent Antitumor Activity
• Synthesis of the Nonatetracontapeptide corresponding to the Sequence proposed for Thymopoietin II
• 創薬科学賞受賞 インスリン抵抗性改善薬ピオグリタゾンの創製
• MCHレセプターおよびそのアンタゴニスト (特集 肥満症の分子メカニズム--アディポサイエンス最前線)
• ゲノム情報を活用した21世紀の創薬
• 創薬技術はどこまで進むか (21世紀の医療と創薬--これからの医療・薬物療法はどう変わるか) -- (第2章 21世紀の創薬と薬物療法)
• 薬のディスカバリーはどのように行われるか (特集 新しい医薬品をどう創り,どう評価するか)
• 21世紀の創薬
• 画期的な新薬の研究開発(新薬開発体制における戦略的展開)
• 技術賞受賞アンジオテンシンII受容体拮抗薬カンデサルタンシレキセチルの創製
• ゲノム研究と創薬の可能性(ゲノム科学と医療)
• 遺伝子研究と創薬
• 技術賞受賞トロンボキサンA_2受容体拮抗薬セラトロダストの創製研究
• 第17回ペプチド化学討論会
• エンドセリン遺伝子のクロ-ニング
• Synthesis of a Wasp Venom Tetradecapeptide, Mastoparan, with a New Cleaving System for 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) Amino-Protecting Group
• リュープリン(LH-RH super-agonist)の研究開発 (最先端創薬--戦略的アプローチと先端的医薬品) -- (先端的医薬品--単一成分に対するアプローチ)
• ペプチドから非ペプチドへ
• ポストゲノム時代を迎えた医薬品研究開発
• オーファン受容体のリガンド探索とゲノム創薬 (特集 薬理ゲノミックスとゲノム創薬戦略--日本薬学会第120年会より)
• Synthetic Studies on Enkephalin Analogs. III. A Highly Potent Enkephalin Analog, H-Tyr-D-Met (O)-Gly-Phe-NHNH-CO-CH_2CH_3
• Synthesis of the Nonacosapeptide corresponding to the Proposed Amino Acid Sequence of Turkey Glucagon
• Structure-Taste Relationships of L-Aspartyl-Aminomalonic Acid Diesters
• リュープリン (高活性LH-RH誘導体) の研究開発
• ペプチドの医薬品への応用 (アミノ酸・核酸特集)
• 生理活性ペプチドの合成
• ゲノム創薬の展望
• 創薬の移り変わり

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