Synthesis of Peptides related to Corticotropin (ACTH). IV. Syntheses of β-Alanine^1-, γ-Aminobutyric Acid^1-, Sarcosine^1-, Proline^1- and Lysine^1-α^<1-24>-ACTH

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概要

• 論文の詳細を見る
• 社団法人日本薬学会の論文
• 1970-06-25

著者

• 西村 紀

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品中央研

• 畑中 千年

  Chemical Research Laboratories, Research and Developmemt Division, Takeda Chemical Industries, Ltd.

• 畑中 千年

  Research and Development Division, Takeda Chemical Industries, Ltd

• 畑中 千年

  Research And Development Division Takeda Chemical Industries Ltd

関連論文

• 医薬品としてのペプチドおよびタンパク質 (タンパク質化学の新展開)
• Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
• Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis
• The Synthesis of Serum Thymic Factor and Its Analogs
• Synthesis and Pharmacology of TRH Analogs to separate Central Nervous Action from Endocrine Activity
• Synthesis of Salmon Endorphin
• Studies on Peptides. LXXX. N^G-Mesitylene-2-sulfonylarginine
• New Method for Removing the S-p-Methoxybenzyl and S-t-Butyl Groups of Cysteine Residues with Mercuric Trifluoroacetate
• Studies on Peptides. LX. Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Bovine Adrenocorticotropic Hormone
• p-Methoxybenzenesulfonyl as a Protecting Group of Guanidino Function in Peptide Synthesis
• Synthesis of Peptides related to Corticotropin (ACTH). IX. Application of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Ester Procedure to the Synthesis of Human Adrenocorticotropic Hormone (α_h-ACTH)
• Synthesis of Peptides related to Corticotropin (ACTH). VIII. Synthesis of α^-ACTH
• The Use of N-Hydroxy-5-norbornene-2,3-dicarboximide Active Esters in Peptide Synthesis
• Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis. I. Synthesis and Properties of Isobornyloxycarbonylamino Acids
• Synthesis of Peptides related to Corticotropin (ACTH). VII. Syntheses and Biological Activity of Leucine^7-α^-ACTH and N^α-Methyltryptophan^9-α^-ACTH
• Synthesis of Peptides Related to Corticotropin (ACTH). VI. Syntheses and Biological Activity of the Peptides Corresponding to the Amino Acid Sequences 4-23,5-23,6-24 and 7-23 in ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). V. Syntheses of Leucine^4- and Isoleucine^4-α^-ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). IV. Syntheses of β-Alanine^1-, γ-Aminobutyric Acid^1-, Sarcosine^1-, Proline^1- and Lysine^1-α^-ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). III. Syntheses of α^_2-ACTH and β-Alanine^1-α^_2-ACTH
• Synthesis of Peptides related to Corticotropin (ACTH). I. Synthesis of α^_2-ACTH-tricosapeptide Amide
• Synthesis of Peptides related to Corticotropin (ACTH). II. Synthesis of the Protected Peptides Corresponding to the Sequence 1-3,4-6,7-10,11-14,15-19 and 20-23 of ACTH
• The Use of Esters of Simple Ketoximes in Peptide Synthesis
• Studies on Peptides. XIV. Synthesis of Lysyl-S-benzylcysteinylalanylglutaminyl-S-benzyl-cysteinylhistidine, a Peptide related to Horse Heart Cytochrome C.
• Synthesis of Some Di-and Tri-Substituted Analogs of Luteinizing Hormone Releasing Hormone (LH-RH)
• Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis.IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RH/FSH-RH)
• Synthesis and Biological Activity of 8-L-Ala-Motilin and 8-D-Ala-Motilin
• Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities
• A New Mast Cell Degranulating Peptide "Mastoparan" in the Venom of Vespula lewisii
• Synthesis of the Dodecapeptide Amide corresponding to the Entire Amino Acid Sequence of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
• Synthesis of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
• Studies on Antidiabetic Agents. X. Synthesis and Biological Activities of Pioglitazone and Related Compounds
• Application of a Unique Automated Synthesis System for Solution-phase Peptide Synthesis
• 最近の生理活性ペプチド研究--立体構造と作用機作を中心に (アミノ酸・核酸)
• 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) : a New Amino and Imidazole Protecting Group in Peptide Synthesis
• Synthesis of the Heptadecapeptide corresponding to the Full Sequence of Dynorphin
• Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine
• Use of the 4-Methoxy-2,6-dimethylbenzenesulfonyl (Mds) Group to Synthesize Dynorphin [1-13] and Related Peptides
• 29 担子菌酵母,Tremella mesentericaの接合管形成誘導物質
• 1B-12 Saccharomyces kluyveriの性フェロモン, 特にSaccharomyces cerevisiaeの性フェロモンとの関連性
• 生理活性ペプチドの合成--構造-活性相関を中心として (アミノ酸・核酸特集)
• Synthesis of the Carboxy Terminal Fragments of the β-Subunit of the Human Chorionic Gonadotropin(hCG)
• 1 Tremella mesenterica の接合管誘導物質,tremerogen A-10の化学構造と,合成類縁体の生物活性
• New Peptide Models for Studying Racemization
• Synthesis of the Nonacosapeptide corresponding to Mammalian Glucagon
• Synthesis of Porcine Motilin and Its D-Phe^1-Analog by the Use of Methanesulfonic Acid
• 新しい天然生理活性物質の研究--天然由来ペプチド研究の動向(総説シリ-ズ--現代医学の焦点-46-)
• New Protecting Groups for the Indole Ring of Tryptophan in Peptide Synthesis : 2,4,6-Trimethoxybenzenesulfonyl and 4-Methoxy-2,3,6-trimethylbenzenesulfonyl Groups
• Synthesis of immunologically Active Muramyl Dipeptide Derivatives containing a Quinonyl Moiety via Aminoacyl Intermediates
• Muramyl Dipeptide(MDP)誘導体の合成と免疫アジュバント活性
• Novel Quinonyl Derivatives of Muramyl Dipeptide Possessing Potent Antitumor Activity
• Synthesis of the Nonatetracontapeptide corresponding to the Sequence proposed for Thymopoietin II
• 創薬科学賞受賞 インスリン抵抗性改善薬ピオグリタゾンの創製
• MCHレセプターおよびそのアンタゴニスト (特集 肥満症の分子メカニズム--アディポサイエンス最前線)
• ゲノム情報を活用した21世紀の創薬
• 創薬技術はどこまで進むか (21世紀の医療と創薬--これからの医療・薬物療法はどう変わるか) -- (第2章 21世紀の創薬と薬物療法)
• 薬のディスカバリーはどのように行われるか (特集 新しい医薬品をどう創り,どう評価するか)
• 21世紀の創薬
• 画期的な新薬の研究開発(新薬開発体制における戦略的展開)
• 技術賞受賞アンジオテンシンII受容体拮抗薬カンデサルタンシレキセチルの創製
• ゲノム研究と創薬の可能性(ゲノム科学と医療)
• 遺伝子研究と創薬
• 技術賞受賞トロンボキサンA_2受容体拮抗薬セラトロダストの創製研究
• 第17回ペプチド化学討論会
• エンドセリン遺伝子のクロ-ニング
• Synthesis of a Wasp Venom Tetradecapeptide, Mastoparan, with a New Cleaving System for 4-Methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) Amino-Protecting Group
• Synthesis of Tricholomic Acid. IV. Synthesis of DL-threo-α-Amino-3-oxo-5-isoxazolidineacetic Acid
• リュープリン(LH-RH super-agonist)の研究開発 (最先端創薬--戦略的アプローチと先端的医薬品) -- (先端的医薬品--単一成分に対するアプローチ)
• ペプチドから非ペプチドへ
• ポストゲノム時代を迎えた医薬品研究開発
• オーファン受容体のリガンド探索とゲノム創薬 (特集 薬理ゲノミックスとゲノム創薬戦略--日本薬学会第120年会より)
• Synthetic Studies on Enkephalin Analogs. III. A Highly Potent Enkephalin Analog, H-Tyr-D-Met (O)-Gly-Phe-NHNH-CO-CH_2CH_3
• Synthesis of the Nonacosapeptide corresponding to the Proposed Amino Acid Sequence of Turkey Glucagon
• Structure-Taste Relationships of L-Aspartyl-Aminomalonic Acid Diesters
• リュープリン (高活性LH-RH誘導体) の研究開発
• A New Procedure for the Pentachlorophenylation of N-Protected Amino Acids
• A New Reagent for the tert-Butyloxycarbonylation of Amino Acids
• Synthetic Studies on Enkephalin Analogs. II. Enhanced Analgesic Activity of H-Tyr-D-Ala-Gly-Phe-NHNH-CO-CH_2CH_3 following N-Methylation of Tyr and Phe
• Synthetic Studies on Enkephalin Analogs. I. Potent Analgesic Activity of H-Tyr-D-Ala-Gly-Phe-NHNH-CO-R (R=Lower Alkyl)
• ペプチドの医薬品への応用 (アミノ酸・核酸特集)
• Synthesis of a Highly Potent Analog of Luteinizing Hormone Releasing Hormone (LH-RH) : [Des-Gly-NH_2^, Pro-NH-Et^9]-LH-RH
• Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis. II. Synthesis of Bradykinin
• 生理活性ペプチドの合成
• ゲノム創薬の展望
• 創薬の移り変わり

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