Synthesis of Peptides related to Corticotropin (ACTH). VIII. Synthesis of α^<1-24>-ACTH

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概要

• 論文の詳細を見る

• A tetracosapeptide (α^<1-24>-ACTH) corresponding to the first 24-amino acid sequence of corticotropin (ACTH) was synthesized by a classical method. The ester exchange method using pentachlorophenyl trichloroacetate (TCAOPCP) was employed successfully for condensation of the main fragments having C-terminal glycine and proline. All protecting groups of the tetracosapeptide were removed using the hydrogen fluoride method. The synthetic peptide thus obtained exhibited an activity of ca. 90 units/mg in in vivo steroidogenic assay.

• 社団法人日本薬学会の論文
• 1975-05-25

著者

• 西村 紀

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 藤野 政彦

  武田薬品中央研

• 西村 紀

  Medical Research Laboratory, Takeda Chemical Ind. Ltd.

• 藤野 政彦

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 畑中 千年

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 畑中 千年

  Research and Development Division, Takeda Chemical Industries, Ltd

• 畑中 千年

  Research And Development Division Takeda Chemical Industries Ltd

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