Application of an Automated Synthesis Suite to Parallel Solution-Phase Peptide Synthesis
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概要
- 論文の詳細を見る
An in-house developed automated synthesis suite was used to prepare a library of 72 tetrapeptide derivatives, the starting materials for pharmaceutically attractive pentapeptides, employing a convergent strategy. An initial set of 18 dipeptides were synthesized on a large-scale (100-1000g) using automated synthesis workstations, and then 72 tetrapeptides were synthesized on a medium scale (5-10g) using an automated system. Each di- or tetrapeptide was prepared in a single operating cycle using a modified methanesulfonic acid method, then a sub-library of 56 pentapeptides were synthesized in parallel, on a small-scale (100mg-1g) using a robotic workstation.
- 社団法人日本薬学会の論文
- 2001-09-01
著者
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小島 憲道
東大総合文化
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黒田 規敬
熊本大学大学院
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小島 憲道
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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KITADA Chieko
Discovery Research Laboratories I, Pharmaceutical Discovery Research Division, Takeda Chemical Indus
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HATTORI Tomoe
Showa Pharmaceutical University
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Kuroda Noritaka
Discovery Research Laboratories V Discovery Research Division Takeda Chemical Industries Ltd.
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Kuroda Noritaka
Institute For Materials Science Tohoku University
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HATTORI Taeko
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries.Ltd.
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FUJIOKA Yoko
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries.Ltd.
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CORK David
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries.Ltd.
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SUGAWARA Tohru
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries.Ltd.
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Kitada C
Takeda Chemical Ind. Ltd. Ibaraki Jpn
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Kitada Chieko
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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Kitada Chieko
Discovery Research Division Takeda Chemical Industries Ltd
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Kojima Norimichi
Graduate School Of Arts And Science University Of Tokyo
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Cork David
Institute Of Biofunctional Research C/o National Cardiovascular Center
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Cork David
Discovery Research Laboratories V Discovery Research Division Takeda Chemical Industries.ltd.
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Fujioka Y
Discovery Research Laboratories V Discovery Research Division Takeda Chemical Industries.ltd.
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Sugawara T
Discovery Research Laboratories V Discovery Research Division Takeda Chemical Industries Ltd.
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Kuroda N
Nec Corp. Ibaraki Jpn
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KURODA Noritaka
Research Institute for Iron, Steel and Other Metals Tohoku University : Tohoku University : Physics Department, Purdue University
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SUGAWARA Tohru
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries, Ltd.
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