Solution-Phase Automated Synthesis of Tripeptide Derivatives
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概要
- 論文の詳細を見る
An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor, 2) formation of emulsions, and 3) use of the restricted solvent, dichloromethane. As an application of the automated synthesis apparatus, 216 fragment tripeptide derivatives were synthesized systematically using the MSA method, in excellent yield and with increased efficiency.
- 社団法人日本薬学会の論文
- 2001-09-01
著者
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小島 憲道
東大総合文化
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黒田 規敬
熊本大学大学院
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小島 憲道
Department Of Basic Science Graduate School Of Arts And Sciences The University Of Tokyo
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KITADA Chieko
Discovery Research Laboratories I, Pharmaceutical Discovery Research Division, Takeda Chemical Indus
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HATTORI Tomoe
Showa Pharmaceutical University
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Kuroda Noritaka
Discovery Research Laboratories V Discovery Research Division Takeda Chemical Industries Ltd.
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Kuroda Noritaka
Institute For Materials Science Tohoku University
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HATTORI Taeko
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries.Ltd.
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SUGAWARA Tohru
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries.Ltd.
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Kitada C
Takeda Chemical Ind. Ltd. Ibaraki Jpn
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Kitada Chieko
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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Kitada Chieko
Discovery Research Division Takeda Chemical Industries Ltd
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Kojima Norimichi
Graduate School Of Arts And Science University Of Tokyo
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Sugawara T
Discovery Research Laboratories V Discovery Research Division Takeda Chemical Industries Ltd.
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Kuroda N
Nec Corp. Ibaraki Jpn
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KURODA Noritaka
Research Institute for Iron, Steel and Other Metals Tohoku University : Tohoku University : Physics Department, Purdue University
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SUGAWARA Tohru
Discovery Research Laboratories V Discovery Research Division, Takeda Chemical Industries, Ltd.
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