The Synthesis and Xanthine Oxidase Inhibitory Activity of Pyrazolo[3,4-d]pyrimidines

スポンサーリンク

概要

• 論文の詳細を見る

• A series of compounds possessing the pyrazolo[3,4-d]pyrimidine nucleus were synthesized, characterized and screened for the ability to inhibit xanthine oxidase activity. The compounds were compared with 4-hydroxypyrazolo[3,4-d]pyrimidine (4), which showed 100% inhibition at a 33 μmole concentration. The structure-activity relationships of the synthesized compounds were discussed. 4-Amino-6-hydroxy-3-phenyl-pyrazolo[3,4-d]pyrimidine (30b) and 4-amino-3-(p-chlorophenyl)-6-hydroxypyrazolo[3,4-d]pyrimidine (30c) were found to be as potent inhibitors as allopurinol.

• 公益社団法人日本薬学会の論文
• 1973-05-25

著者

• 小林 栄

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 小林 栄

  Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

関連論文

• Isobornyloxycarbonyl Function, a New Convenient Amino-Protecting Group in Peptide Synthesis.IV. Synthesis of Gonadotropin-Releasing Hormone (Gn-RH or LH-RH/FSH-RH)
• The X-ray Analysis of Lenthionine, an Odorous Substance of Shiitake, an Edible Mushroom
• The Synthesis and Xanthine Oxidase Inhibitory Activity of Pyrazolo[3,4-d]pyrimidines

スポンサーリンク