1-Indancarboxylic Acids. IV. A Convenient Synthesis of Antiinflammatory 4-Aroyl-1-indancarboxylic Acids and Their Absolute Configurations
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概要
- 論文の詳細を見る
Antiinflammatory 4-aroyl-1-indancarboxylic acids (I) were synthesized from the corresponding 4-aroyl-1-indanones (XI) by the one-carbon homologation reaction using p-toluenesulfonylmethylisocyanide (TosMIC, II) via 4-aroyl-1-indancarbonitriles (XIV). Among them, three compounds (Ia, b and c) were resolved into their enantiomers and it was found that the antiinflammatory activity virtually resides in the levo isomers, the absolute configurations of which were assigned the sinister series by the optical rotatory dispersion spectra.
- 社団法人日本薬学会の論文
- 1978-06-25
著者
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青野 哲也
Resarch & Development Division Takeda Chemical Industries Ltd.
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岸本 彰二
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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岸本 彰二
Central Research Division, Takeda Chemical Industries, Ltd.
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青野 哲也
Central Research Division, Takeda Chemical Industries, Ltd.
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野口 俊作
Central Research Division, Takeda Chemical Industries, Ltd.
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荒木 義昭
Central Research Division, Takeda Chemical Industries, Ltd.
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野口 俊作
Central Research Division Takeda Chemical Industries Ltd.
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岸本 彰二
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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荒木 義昭
Central Research Division Takeda Chemical Industries Ltd.
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