Aldol Condensation of Corticoids with Formaldehyde. II. 21-Hydroxymethylation of Reichstein's Substance S, Dexamethasone and Deoxycorticosterone
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概要
- 論文の詳細を見る
21-Hydroxymethyl-Reichstein's substance S (III), 21-hydroxymethyldexamethasone (IV ), 21-hydroxymethyldeoxycorticosterone (VI) and 21,21-bis(hydroxymethyl)deoxycorticosterone (VII) were synthesized by the aldol condensation of the parent steroids with formaldehyde in the presence of sodium acetate. When 21-hydroxymethyl-Reichstein's substance S diacetate (VIII) and 21-hydroxymethyldeoxycorticosterone diacetate (X) were passed through a column of alumina, 21-methyl-17α-hydroxypregn-4-ene-3,20,21-trione acetate(IX) and 21-methylpregn-4-ene-3,20,21-trione (XI) were obtained. The diketone (XI) underwent further decomposition in the air to give androst-4-ene-3,17-dione.
- 社団法人日本薬学会の論文
- 1964-10-25
著者
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野口 俊作
Central Research Division, Takeda Chemical Industries, Ltd.
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野口 俊作
Central Research Division Takeda Chemical Industries Ltd.
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野口 俊作
Research Laboratories, Takeda Chemical Industries, Ltd.
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森田 桂
Research Laboratories, Takeda Chemical Industries, Ltd.
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中山 冨士子
Research Laboratories, Takeda Chemical Industries, Ltd.
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野口 俊作
Research Laboratories Takeda Chemical Industries Ltd.
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森田 桂
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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森田 桂
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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森田 桂
Research And Development Division Takeda Chemical Industries Ltd.
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中山 冨士子
Research Laboratories Takeda Chemical Industries Ltd.
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