Synthesis of 20α-Hydroxy-16-oxosteroids and the C-20 Configuration of Δ^<17(20)>-16-Ocosteroids

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概要

• 論文の詳細を見る

• Treatment of 16β, 20α-dihydroxysteroids, Ia, Ib, and Ic, with Na_2Cr_2O_7-H_2SO_4 reagent in ether-benzene-tetrahydrofuran resulted in a selective oxidation of the 16-hydroxyl group to afford 20α-hydroxy-16-oxosteroids, IIIa, IIIb, and IIIc. IIIa, IIIb, and the 20-acetates, IVa and IVb, were treated with TsCl, KHCO_3,K_2CO_3 or alumina to afford a mixture of cis and trans 17(20)-16-oxosteroids (V and VI). The C-20 configuration of the isomers, V and VI, was established on the basis of the nuclear magnetic resonance spectra.

• 社団法人日本薬学会の論文
• 1964-10-25

著者

• 今西 正之

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division Takeda Chemical Industries Ltd.

• 今西 正之

  Central Research Division Takeda Chemical Industries Ltd.

• 野口 俊作

  Research Laboratories, Takeda Chemical Industries, Ltd.

• 今西 正之

  Research Laboratories, Takeda Chemical Industries, Ltd.

• 森田 桂

  Research Laboratories, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Research Laboratories Takeda Chemical Industries Ltd.

• 森田 桂

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 森田 桂

  Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

• 森田 桂

  Research And Development Division Takeda Chemical Industries Ltd.

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