Aldol-Condensation of Corticoids with Formaldehyde. Syntheses of 21-Hydroxy-methyl-corticoids and 21-Methyl-11β, 17α-dihydroxy-pregna-1,4-diene-3,20,21-trione 17-Acetate.
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概要
- 論文の詳細を見る
21-Hydroxymethylprednisolone (II), 21-hydroxymethylhydrocortisone (VIII) and 21,21-bis (hydroxymethyl) prednisolone (VI) were synthesized by the aldol condensation of the parent steroids with formaldehyde. When 21-hydroxymethylprednisolone diacetate (III) was passed through a column of aluminum oxide, a light yellow compound was obtained and the structure was assigned to 21-methyl-11β, 17α-dihydroxypregna-1,4-diene-3,20,21-trione 17-acetate (X). The mechanism of the formation of X from III was also proposed.
- 社団法人日本薬学会の論文
- 1963-10-25
著者
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野口 俊作
Central Research Division, Takeda Chemical Industries, Ltd.
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野口 俊作
Central Research Division Takeda Chemical Industries Ltd.
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野口 俊作
Research Laboratories, Takeda Chemical Industries, Ltd.
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森田 桂
Research Laboratories, Takeda Chemical Industries, Ltd.
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野口 俊作
Research Laboratories Takeda Chemical Industries Ltd.
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森田 桂
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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森田 桂
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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森田 桂
Research And Development Division Takeda Chemical Industries Ltd.
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