Chemical Modification of Fumagillin. III. Modification of the Spiro-epoxide
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概要
- 論文の詳細を見る
The spiro-epoxy group of fumagillol (2) was selectively modified and several analogues of AGM-1470 (3) with a (dialkyl)-β-hydroxyethylsulfonium moiety were prepared. These analogues were found to inhibit angiogenesis induced by basic fibroblast growth factor in the rat micropocket assay. They also inhibited the growth of M5076 cells in vivo, but did not affect the body weight change of the tested mice during the assay.
- 社団法人日本薬学会の論文
- 1995-04-15
著者
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山本 敏弘
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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圓井 省吾
Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,
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須藤 勝一
Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,
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秋元 浩
Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,
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岸本 彰二
Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,
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岸本 彰二
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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岸本 彰二
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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須藤 勝一
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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圓井 省吾
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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秋元 浩
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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Yamamoto T
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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