Chemical Modification of Fumagillin. II. 6-Amino-6-deoxyfumagillol and Its Derivatives
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概要
- 論文の詳細を見る
6-Amino-6-deoxyfumagillol (5) was synthesized by reductive amination of 6-oxo-6-deoxyfumagillol (4), which was obtained by oxidation of fumagiollol (2). The reduction proceeded stereoselectively by the equatorial attack of hydride and 5 was found to have the same stereochemistry as that of 2. Several derivatives of 5 were prepared and most of them showed anti-angiogenic activity comparable to that of fumagillol derivatives.
- 社団法人日本薬学会の論文
- 1992-03-25
著者
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圓井 省吾
Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,
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岸本 彰二
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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圓井 省吾
Chemistry Ressearch Laboratories, Takeda Chemical Industries, Ltd.
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岸本 彰二
Chemistry Research Laboratories, Takeda Chemical Industries, Ltd.
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岸本 彰二
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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圓井 省吾
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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