Transferrin Is Not Involved in the Entry of^<67>Ga into Hepatocytes from Regenerating Liver of Partially Hepatectomized Rats

概要

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Ever since the first observation of ^<67>Ga accumulation in tumors and inflammatory lesions, ^<67>Ga has been used to detect various tumors and inflammations. The aims of this study were to clarify whether or not transferrin is involved in the uptake of ^<67>Ga by the regenerating liver after partial hepatectomy. The uptake of ^<67>Ga by the liver of rats reached a maximum 2d after partial hepatectomy. In order to inhibit the binding of ^<67>Ga to transferrin in the blood, FeCl_3 was administered 5min before the injection of ^<67>Ga. The administration of FeCl_3 decreased the uptake of ^<67>Ga by the liver of the partially hepatectomized rats, suggesting that transferrin is involved in the uptake by the liver. However, ^<67>Ga was taken up only slightly by hepatocytes obtained from the liver of these rats. We conclude that transferrin is involved in the uptake of ^<67>Ga by the liver tissue of partially hepatectomized rats but is not involved in its entry into the hepatocytes. Only a slight amount of gallium-67 enters the hepatocytes, and may accumulate primarily in the extracellular matrix of the liver tissue of these rats.
公益社団法人日本薬学会の論文
2001-12-01