Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
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概要
- 論文の詳細を見る
Many medicines exist which can cause pruritus (itching) as "serious adverse events." Many severe pruritic conditions respond poorly to histamine H1 receptor antagonists; there is no generally accepted antipruritic treatment. Recently described histamine H4 receptors are expressed in haematopoietic cells and have been linked to the pathology of allergy and asthma. We previously reported their expression in human dermal fibroblasts; in this study we have investigated H4 receptor expression in human epidermal tissue and found it to be greater in keratinocytes in the epidermal upper layer than in the lower layer. We have also investigated the effect of histamine H4 receptor antagonists on histamine H1 receptor antagonist-resistant pruritus using a mouse model. Scratching behavior was induced by histamine (300nmol) or substance P (100nmol) injected intradermally into the rostral part of the back of each mouse. Fexofenadine, a histamine H1 receptor antagonist, reduced scratching induced by histamine but not by substance P, whereas JNJ7777120, a histamine H4 receptor antagonist, significantly reduced both histamine- and substance P-induced scratching. These results suggest that H4 receptor antagonists may be useful for treatment of H1 receptor antagonist-resistant pruritus.
- 2009-08-01
著者
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ODA Manabu
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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UENO Koichi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Yamaura Katsunori
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Suwa Eriko
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
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Sato Hiromi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Ueno K
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Sato Hiromi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Ueno Koichi
Departments Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Ch
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Suwa Eriko
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Oda Manabu
千葉大学 薬学研究院高齢者薬物学
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Oda Manabu
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno K
Kinki Univ. Nara Jpn
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Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Yamaura Katsunori
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Yamaura Katsunori
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
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Suzuki Masahiko
Department Of Orthopaedic Surgery Chiba University Graduate School Of Medicine
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Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Sato Hiromi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University, 6-6-11-1302 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
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Oda Manabu
Department of Electrical and Electronic Engineering, Tokyo Institute of Technology, Meguro, Tokyo 152-8552, Japan
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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