HYPOCALCEMIC EFFECT OF ACETYLSALICYLIC ACID IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Oral administration of acetylsalicylic acid (ASA) at a dose of 200 mg/kg produced a decrease in both total plasma calcium and plasma ionic calcium levels in rats. The percent changes from controls in both total and ionic calcium were similar, being approximately 13% at 3 hr after the administration. A significant (p<0.01) decrease in plasma calcium level was also observed at 4 hr after oral administration of salicylic acid at a dose level of 177 mg/kg. However, oral administration of other non-steroidal anti-inflammatory agents such as indomethacin failed to decrease plasma calcium levels in rats. The hypocalcemic effect of ASA was recognized in parathyroidectomized rats, but neither in thyroparathyroidectomized nor in thyroidectomized rats. Therefore, the data suggested that the action of ASA might be mediated by stimulation of calcitonin release, but not by inhibition of prostaglandin biosynthesis.
- 公益社団法人日本薬学会の論文
著者
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SAKAI Takeshi
Department of Physics and Research Center for the Early Universe, The University of Tokyo
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NAMINOHIRA SHIGERU
Department of Toxicology, School of Pharmacy, Hokuriku University
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Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Kitagawa Haruo
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Blotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Kitagawa Haruo
Analytical And Metabolic Research Laboratories And Biological Research Laboratories Sankyo Co. Ltd.:
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Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Naminohira Shigeru
Department Of Toxicology School Of Pharmacy Hokuriku University
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Saito Haruo
Department Of Toxicology School Of Pharmacy Hokuriku University
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Sakai Takeshi
Department Of Toxicology School Of Pharmacy Hokuriku University
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MASUMURA HIDEMI
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicolo
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Sakai Takeshi
Department Of Electrical Engineering College Of Engineering University Of Osaka Prefecture
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Saito Haruo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Masumura Hidemi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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NAMINOHIRA Shigeru
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
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SAKAI TAKESHI
Department of Chemical Engineering, Gunma University
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