Analysis of Correlation between Prescription Drugs for Climacteric Disorders and CA Repeat Polymorphism of Estrogen Receptor β Gene
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概要
- 論文の詳細を見る
To establish drug therapy for climacteric disorders based on CA repeat polymorphism in the estrogen receptor β gene, the present study investigated the issuance of prescriptions to patients with climacteric disorders in relation to CA repeat polymorphism. Prescription data used in this study included that for drugs that were prescribed for more than 3 months to 63 patients undergoing treatment for climacteric disorders. The 195 prescriptions analyzed included traditional Kampo medicines (49.7%), central nervous system medicines (26.7%) and Hormones (21.5%). The scale of combination therapy with Kampo to monotherapy with Kampo was 2.14 for SS genotype subjects, 1.43 for SL genotype subjects and 0.86 for LL genotype subjects. Thus the usage of combination therapy in SS subjects was 2.5 times greater than that in LL subjects. The percentages of the medicines predominantly prescribed for treatment of climacteric disorders-Kamishoyosan, Keishibukuryogan and Tokishakuyakusan-for each genotype were 72.7% for SS, 47.1% for SL and 38.5% for LL, and the percentage for the SS genotype was significantly higher than that for the LL genotype. The prescription rate for Keishibukuryogan for patients with the SS genotype was 31.8% versus 10.0% for the other 2 genotypes, the rate for SS being significantly higher. In conclusion, the use of CA repeat polymorphism in addition to symptoms in the selection of drugs for climacteric disorders may allow therapy to be personalized.
- 日本医療薬学会の論文
- 2006-01-10
著者
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UENO Koichi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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Ueno Koichi
Dep. Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chiba Uni
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NEGISHI Etsuko
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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TAKEO Chikari
Department of Clinical Cell Biology, Chiba University Graduate School of Medicine
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Takeo Chikari
Department Of Clinical Cell Biology Chiba University Graduate School Of Medicine
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Takeo Chikari
Department Of General Medicine Chiba Prefectural Togane Hospital
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Nakajima Aya
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Amano Keiko
Department Of General Medicine Chiba Prefectural Togane Hospital
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Hirai Aizan
Department Of Internal Medicine Chiba Prefectural Togane Hospital
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Negishi Etsuko
Dep. Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences Chiba U
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Negishi Etsuko
Graduate School Of Pharmaceutical Sciences Chiba University
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Hisamitsu Kenichi
Office of Clinical Trial, Chiba Prefectural Togane Hospital
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Hisamitsu Kenichi
Office Of Clinical Trial Chiba Prefectural Togane Hospital
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Nakajima Aya
Department Of Environmental Systems Engineering Kochi University Of Technology
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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