Comparative study of histamine H4 receptor expression in human dermal fibroblasts
スポンサーリンク
概要
- 論文の詳細を見る
The histamine H4 receptor (H4R) is the newest receptor identified of four histamine receptors. Its expression in numerous immune and inflammatory organs has been implicated in relation to immune systems and allergic diseases. In the present study, we demonstrate the expression of H4R in human dermal fibroblasts and investigate changes in its expression level when stimulated by histamine, phorbol 12-myristate 13-acetate (PMA), lipopolysaccharides (LPS), dexamethasone and indomethacin. Histamine and PMA showed no effects on H4R expression. LPS and indomethacin up-regulated H4R mRNA expression, and 20μM dexamethasone increased H4R protein levels. These results indicate a good prospective for this new receptor in the development of effective treatments of inflammatory diseases and pruritus or for the appropriate prevention of toxicities.
- 日本トキシコロジー学会の論文
- 2008-10-01
著者
-
UENO Koichi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
-
Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
-
Sato Hiromi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
-
Ikawa Yoshiko
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
-
Ikawa Yoshiko
千葉大学 薬学研究院高齢者薬剤学
-
Ikawa Yoshiko
千葉大学 大学院薬学研究院高齢者薬剤学研究室
-
Ikawa Yoshiko
千葉大学 大学院薬学研究院高齢者薬物学
-
Ueno Koichi
Dep. Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chiba Uni
-
Shiba Kayoko
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences,Chib
-
Ohki Emi
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences,Chib
-
Mutoh Nanami
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences,Chib
-
Ohki Emi
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
-
Mutoh Nanami
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
-
Shiba Kayoko
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
-
Sato Hiromi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
-
Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
-
Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
-
Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
-
Ikawa Yoshiko
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
-
Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
-
Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
-
Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
-
Sato Hiromi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University, 6-6-11-1302 Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan
-
UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
関連論文
- Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist
- The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cells
- Toxicokintic and toxicodynamic analysis of clofibrate based on free drug concentrations in nagase analbuminemia rats (NAR)
- Enhanced Effect of Connexin 43 on Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
- Adenosine A_1 receptors using 8-dicyclopropylmethyl-1-[^C]methyl-3-propylxanthine PET in Alzheimer's disease
- PE-415 Induction of Diacylglycerol O-acyltransferase 1 Gene Induces Tumor Necrosis Factor-α Gene Expression in 3T3-L1 Adipocytes(Diabetes/Obesity/Metabolic syndrome-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Surgical Treatment of Renal Cell Carcinoma with Tumor Thrombi in the Inferior Vena Cava
- OJ-117 Predictors of Deep Venous Thrombosis and Pulmonary Arterial Thromboembolism after Total Knee Replacement Using Multislice CT in Logistic Regression Models(Thromboembolism/Antithrombotic therapy/Thrombolysis-2 (H) OJ20,Oral Presentation (Japanese),T
- A COMPARATIVE STUDY OF HISTAMINE ACTIVITIES ON DIFFERENTIATION OF OSTEOBLASTS AND OSTEOCLASTS
- Incidence of Asymptomatic Pulmonary Arterial Thrombi Following Deep Vein Thrombi in Total Knee Arthroplasty : Comparative Evaluation of Three Techniques (Thrombosis/Thrombolysis 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Socie
- Establishment and Pathophysiological Characterization of Type 2 Diabetic Mouse Model Produced by Streptozotocin and Nicotinamide(Highlighted paper selected by Editor-in-chief,Pharmacology)
- Comparative study of histamine H4 receptor expression in human dermal fibroblasts
- Expression of Histamine H4 Receptor in Synovial Cells from Rheumatoid Arthritic Patients(Biopharmacy)
- Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)
- Connexin 32 as an Anti-invasive and Anti-metastatic Gene in Renal Cell Carcinoma
- Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene
- ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
- CHARACTERIZATION AND PURIFICATION OF VARIOUS CARBOXYLESTERASE ISOZYMES FROM RAT LIVER MICROSOME
- NAD-MEDIATED POTENTIATION OF ANTI-CARBOXYLESTERASE ACTION OF EPN (5); PARTICIPATION OF MICROSOMAL DEHYDROGENASE (S)
- IN VIVO INHIBITION OF LIPID PEROXIDE FORMATION BY CLOFIBRATE IN THE RAT
- SPECIES DIFFERENCE IN GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES IN RATS, MICE, GUINEA PIGS AND HAMSTERS
- THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
- INDUCTION OF HEPATIC GLUTATHIONE S-TRANSFERASE ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- PERTURBATION OF HEPATIC GLUTATHIONE LEVEL AND GLUTATHIONE RELATED ENZYME ACTIVITIES BY REPEATED ADMINISTRATION OF AMINOPYRINE IN RATS
- CHANGES OF GAMMA-GLUTAMYLTRANSPEPTIDASE ACTIVITY IN THE RAT DURING DEVELOPMENT AND COMPARISON OF THE FETAL LIVER, PLACENTAL AND ADULT LIVER ENZYMES
- ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
- Decrease in protein binding and its effect on toxicokinetics (TK)/toxicodynamics (TD) of diclofenac and propranolol in pregnant rats
- "P-32 In vitro liver injury model induced by P. acnes-LPS in multicellular sphroids composed of rat liver cells formed by rotary culture system.
- CYTOKINE-DEPENDENT IN VITRO RAT LIVER INJURY INDUCED BY P.ACNES AND LPS.
- AGE-ASSOCIATED CHANGE IN HEPATIC MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITIES
- GENERAL PHARMACOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN EXPERIMENTAL ANIMALS
- Induction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
- The Histamine H_2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
- Analysis of Correlation between Prescription Drugs for Climacteric Disorders and CA Repeat Polymorphism of Estrogen Receptor β Gene
- EFFECT OF PRENATAL EXPOSURE OF PARATHION ON HUMORAL IMMUNE FUNCTION IN MICE
- BASAL INVESTIGATION ON THE INTRODUCTION OF DRUG METABOLIZING SYSTEM INTO RAT WHOLE EMBBYO CULTURE SYSTEM
- ON THE DIFFERENT FUNCTION OF CYTOCHROME P-450 ISOZYMES IN LIPID PEROXIDATION
- EFFECTS ON OFFSPRING INDUCED BY ORAL ADMINISTRATION OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE TO THE FEMALE RATS IN PERI-AND POST-NATAL PERIODS
- TERATOLOGICAL STUDY OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RABBITS
- TERATOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RATS
- STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE ON FERTILITY IN RATS
- 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers: Their Cytotoxic Activity
- Neonatal Orbital Teratoma with Intracranial Extension : -Case Report-
- Repeat Hepatectomy for Recurrent Colorectal Metastases
- Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation : a case report
- Longer than 3-Year Survival Following Hepato-Ligamento-Pancreatoduodenectomy for Hilar Cholangiocarcinoma with Vascular Involvement : Report of a Case
- Preparatory hepatic resection with right hepatic vein reconstruction for paracaval liver tumor
- Cholangitis score : a scoring system to predict severe cholangitis in gallstone pancreatitis
- 3倍体コイの誘導とその血液学的特徴(速報)〔英文〕
- 329 Productton of Experimental Acute Liver Injury Model Using Multicellular Spheroids Composed of Rat Parenchymal and Non-parenchymal Liver Cells
- Effect of Nonspecific Binding to Microsomes and Metabolic Elimination of Buprenorphine on the Inhibition of Cytochrome P4502D6(Biochemistry/Molecular Biology)
- Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7
- Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
- Memory and learning-enhancing effect of Daikenchuto, a traditional Japanese herbal medicine, in mice
- Inhibition of the Antibody Production by Acetaminophen Independent of Liver Injury in Mice
- Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine
- O11-09 Reproductive Immunotoxicity of di-(2-ethyihexyl phthalate(DEHP)in rats
- P-10. Fish micronucleus test using kidney, gill and erythrocytes(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- P-09. Micronucleus test using erythrocytes of Carassius species and Zacco platypus for monitoring genotoxic pollutants in river water(Abstracts of the oral and poster presentations)(The 53rd Annual Meeting of the Society of Chromosome Research)
- Chromosome Aberrations and Survival in Normal and Dechorionated Embryos of Misgurnus anguillicaudatus (Cobitidae, Pisces) Exposed to Mitomycin C
- PRODUCTION OF EXPERIMENTAL ACUTE LIVER INJURY MODEL USING THE MULTICELLULAR SPHEROIDS COMPOSED OF RAT LIVER CELLS.
- FORMATION AND LONG-TERM CULTURE OF SPHEROID COMPOSED OF LONG-EVANS CINNAMON(LEC)RAT LIVER CELLS
- EFFECTS OF ANGIOTENSIN II ON THE MEDULLARY NEURONS AND THEIR SENSITIVITY TO ACETYLCHOLINE AND CATECHOLAMINES
- Sex Differences in PPARγ Expressions in Rat Adipose Tissues(Biopharmacy)
- Morphological characteristics of Nigorobuna Carassius auratus grandoculis called Io in Lake Nishino
- Leaching Mechanisms of Di-(2-Ethylhexyl) Phthalate from Polyvinyl-Chloride Tube during the Administration of Enteral Nutrition
- Dissolution of DEHP from PVC Administration Tube : Estimation of DEHP Dissolution Based on HCO 60 Concentration and Drip Conditions
- Development of Patient-Friendly Preparations : Preparation and Characterization of Allopurinol Gelatin Gel Containing Polyethylene(oxide)
- Treatment Strategies for Perianal Rhabdomyosarcoma : Report of Two Cases
- INFLUENCE OF MATERNAL DRUG METABOLISM ON THE FETAL TOXICITY INDUCED BY ACETYLSALICYLIC ACID
- NAD-Coupled Enzymatic Oxidation of O-Ethyl O-p-Nitrophenyl Phenylphosphonothioate (EPN) to Its Oxygen Analog with Liver Microsomes of Rats
- Evaluation of joint laxity against distal traction force upon flexion in cruciate-retaining and posterior-stabilized total knee arthroplasty
- A case of spontaneous hemoarthrosis after a total knee arthroplasty
- Experimenta Congenital Hydrocephalus : -Pathogenetic Processes in Differentiating Brain-
- Development of cPHARM-2E, a Computerized Medical Incident Analysis System
- Formulation Study of Intravesical Oxybutynin Instillation Solution with Enhanced Retention in Bladder
- HYPOCALCEMIC EFFECT OF ACETYLSALICYLIC ACID IN RATS
- A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin
- Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten
- A-55. Arteriovenous Malformation of Vertebro-Basilar Tree Special Emphasis on its Classification and Operative Indcation
- Nucleolus Organizer Regions Detected on Three Chromosome Pairs in Thalassoma cupido (Pisces:Perciformes)
- METHYLENETETRAHYDROFOLATE REDUCTASE AND REDUCED FOLATE CARRIER-1 GENOTYPES AND METHOTREXATE SERUM CONCENTRATIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS
- Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients
- 日本産コイ科魚類の染色体とDNA〔英文〕
- ASPIRIN INHIBITION OF HYPERCALCEMIC EFFECT OF 1α-HYDROXYVITAMIN D3 IN RATS
- A novel animal model of pruritus induced by successive application of glucocorticoid to mouse skin
- Antiallergic Activity of Curcuma longa (II) : Features of inhibitory actions on histamine release from mast cells
- Antiallergic Activity of Curcuma longa (I) : Effectiveness of Extracts Containing Curcuminoids
- Development of a Multi-Scale Electromigration Simulator Based on a Combination of Ultra Accelerated Quantum Chemical Molecular Dynamics and Kinetic Monte Carlo Methods Application to Cu Interconnects Lifetime Simulation
- Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten
- The Histamine H_2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
- Production of Chimeric Loach by Cell Transplantation from Genetically Pigmented to Orange Embryos(Developmental Biology)
- New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis
- Multi-angle observation scheme for bubbles and droplets
- Sex-related differences in pharmacokinetics and pharmacodynamics of anti-hypertensive drugs
- Repeated application of glucocorticoids exacerbate pruritus via inhibition of prostaglandin D_2 production of mast cells in a murine model of allergic contact dermatitis
- Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
- Effects of heptaminol AMP amidate(HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells.
- Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro.
- Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.