Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis(Biopharmacy)

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概要

• 論文の詳細を見る

• While histamine H4 receptor (H4R) has been implicated in immune system disturbances in different organ tissues, the presence and possible roles of H4R in synovial cells (SC) of rheumatoid arthritis (RA) patients has not previously been documented. This study conclusively evidences H4R expression in SC of RA patients by use of RT-PCR method. As RA consists mainly of immunological disturbances in SC of RA patients, this study's findings document a novel histamine action site, and opens potential new avenues to investigate mechanisms and to develop pharmacotherapeutic agents for the disease.

• 社団法人日本薬学会の論文
• 2005-10-01

著者

• UENO Koichi

  Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C

• Suzuki Masahiko

  Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University

• Ikawa Yoshiko

  Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C

• Ikawa Yoshiko

  千葉大学 薬学研究院高齢者薬剤学

• Ikawa Yoshiko

  千葉大学 大学院薬学研究院高齢者薬剤学研究室

• Ikawa Yoshiko

  千葉大学 大学院薬学研究院高齢者薬物学

• Shiono Satoshi

  Laboratory Of Drug Discovery Genomics Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Ueno Koichi

  Dep. Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chiba Uni

• MORIYA Hideshige

  Department of Orthopaedic Surgery (J1), Graduate School of Medicine, Chiba University

• Ohki Emi

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences,Chib

• NEGISHI Etsuko

  Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi

• Ohki Emi

  Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C

• Ueno Koichi

  Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi

• Ueno Koichi

  Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog

• Negishi Etsuko

  Dep. Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences Chiba U

• Negishi Etsuko

  Graduate School Of Pharmaceutical Sciences Chiba University

• Ueno Koichi

  Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un

• Moriya H

  Department Of Orthopaedic Surgery Graduate School Of Medicine Chiba University

• Ikawa Yoshiko

  Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C

• Suzuki Masahiko

  Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University

• Suzuki Masahiko

  Department Of Orthopaedic Surgery Chiba University Graduate School Of Medicine

• Suzuki Masahiko

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• UENO Koichi

  Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University

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