GENERAL PHARMACOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN EXPERIMENTAL ANIMALS
スポンサーリンク
概要
- 論文の詳細を見る
Extensive general pharmacological studies of hydroxypropylmethylcellulose acetate succinate (HPMCAS) were carried out in mice, rats, guinea pigs, rabbits, dogs and frogs. HPMCAS appeared to have no significant effect on the central nervous system, autonomic nervous system and cardiovascular system. Various biological analyses of the blood (including hemolysis and coagulation properties) and urine were unaffected, and the compound showed no significant local anesthetic or vascular permeability. At higher doses of HPMCAS, an increase in secretion of saliva in guinea pigs, a decrease in gastric juice secretion in rats and an increase in rectal temperature in rats were observed, but these effects did not show clear dose-dependence.
- 日本トキシコロジー学会の論文
- 1985-10-31
著者
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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KITAGAWA HARUO
Laboratory of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba
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Ueno K
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences Chi
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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HOSHI Noboru
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluatign and Toxicolo
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YANO Hiroko
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicolo
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HIRASHIMA Kaoru
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicolo
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Hoshi Noboru
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluatign And Toxicolog
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Yano Hiroko
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Kitagawa Haruo
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Blotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Kitagawa H
Faculty Of Pharmaceutical Sciences Chiba University
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Hirashima Kaoru
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Chiba Unive
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Ueno Koichi
Dep. Of Geriatric Pharmacology Graduate School Of Pharmaceutical Sciences Chiba Univ.
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Kitagawa H
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
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