Potentiation of EPN-induced inhibition of liver microsomal carboxylesterase by addition of liver cytosol from 6-aminonicotinamide-treated, starved rats.
スポンサーリンク
概要
- 論文の詳細を見る
Addition of liver cytosol from 16 hr-starved rats treated with 6-aminonicotinamide to rat liver microsomes caused potentiation of the anti-carboxylesterase action of ethyl-p-nitrophenyl phenylphosphonothioate (EPN). This was not found when liver cytosol from non-pretreated rats after 16 hr-starvation was used. This potentiation of EPN-induced inhibition of carboxylesterase may be, at least in part, explained by the fact that treatment of rats with 6-aminonicotinamide resulted in a significant increase in NADPH level in liver cytosol which, in turn, stimulated formation of an EPN oxygen analog, a potent inhibitor of carboxylesterase, through cytochrome P-450-coupled monooxygenase.
- 公益社団法人 日本薬理学会の論文
著者
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Igarashi Takashi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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SUGIYAMA Seiyu
Laboratory of Biochemical Pharmacology and Biotoxicology, Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Scierces, Chiba University
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SUGIYAMA Seiyu
Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology
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KITAGAWA Haruo
Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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SATOH Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
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SATOH Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology. Faculty of Pharmaceutical Sciences, Chiba University
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