EFFECTS OF A DAILY FEEDING-RESTRICTION ON THE REPRODUCTIVE AND DEVELOPMENT TOXICITY PARAMETERS IN FEMALE RATS
スポンサーリンク
概要
- 論文の詳細を見る
On the assumption of that the oral administration of an acid-unstable test compound into the empty stomach could enhance the systemic exposure to the test compound, the non-pregnant and pregnant rats had free access to the diet only for five hours per day. Female rats under the restricted feeding for a period of 21 days took diet at two thirds of the daily food-intake by the control animals, and lost their weight more than 10%. The vaginal smear test in these animals revealed a prolonged estrous cycle and diestrous period over four days. On the other hand, the restricted feeding from Day 0 to Day 17 of gestation suppressed the weight gain of pregnant animals but did not cause any significant influence upon the litter data, incidence of external anomalies or fetal skeletal development. The restricted feeding from Day 0 of gestation to Day 7 of lactation seriously disturbed the nursing behavior and the growth of offspring. These results suggested that the dosing method under the above-mentioned restricted feeding might be applicable to the teratology study but could not be applied to the fertility study nor to the peri- and post-natal study.
- 日本トキシコロジー学会の論文
- 1994-11-30
著者
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KAWAGUCHI Takashi
Department of Toxicology and Safety Assessment, Kawanishi Pharma Research Institute, Nippon Boehring
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Okuda Yasuyuki
Department Of Drug Safety Research Eisai Co. Ltd.
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Maeda Yasunari
Department Of Energy And Hydrocarbon Chemistry Graduate School Of Engineering Kyoto University
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Igarashi Takashi
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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OKADA Fumihiro
Department of Drug Safety Research, Eisai Co., Ltd.
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NIWA Nobuhiro
Department of Drug Safety Research, Eisai Co., Ltd.
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MATSUBARA Yoshio
Department of Drug Safety Research, Eisai Co., Ltd.
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YAMATSU Kiyomi
Department of Drug Safety Research, Eisai Co., Ltd.
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IGARASHI Toshiji
Department of R&D Documentation & Information Technology, Eisai Co., Ltd.
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Igarashi Takashi
Department Of Pediatrics Branch Hospital Faculty Of Medicine University Of Tokyo
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Kawaguchi Takashi
Department Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Osaka Prefect
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Kawaguchi Takashi
Department Of Applied Biological Chemistry College Of Agriculture Osaka Prefecture University
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Kawaguchi Takashi
College Of Agriculture University Of Osaka Prefecture
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Kawaguchi Takashi
Department Of Drug Safety Research Eisai Co. Ltd.
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Niwa Nobuhiro
Department Of Drug Safety Research Eisai Co. Ltd.
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Yamatsu Kiyomi
Department Of Drug Safety Research Eisai Co. Ltd.
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Oakada Fumihiro
Mandom Corp. Central Research Laboratories
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Okada Fumihiro
Department Of Drug Safety Research Eisai Co. Ltd.
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Igarashi T
Eisai Co. Ltd. Ibaraki Jpn
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Kawaguchi T
Department Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Osaka Prefect
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Kawaguchi Takashi
Department Of Toxicology And Safety Assessment Kawanishi Pharma Research Institute Nippon Boehringer
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松原 凱男
Kinki Univ. Nara Jpn
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Matsubara Yoshio
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
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Igarashi Toshiji
Department Of Drug Safety Research. Eisai Co. Ltd.
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Kawaguchi Takashi
Department Of Applied Biological Chemistry College Of Agriculture And Research Institute Of Applied
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Igarashi Toshiji
Department Of Drug Safety Research Eisai Co. Ltd.
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Igarashi Takashi
千葉大学 薬
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Igarashi Takashi
Analytical And Metabolic Research Laboratories And Biological Research Laboratories Sankyo Co. Ltd.:faculty Of Pharmaceutical Sciences Chiba University
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