Differences in the Induction of Carboxylesterase RL4 in Rat Liver Microsomes by Various Perfluorinated Fatty Acids, Metabolically Inert Derivatives of Fatty Acids
スポンサーリンク
概要
- 論文の詳細を見る
Differences in the ability of metabolically inert peroxisome proliferators [perfluoro-n-decanoic acid (PFDA, C_<10>), perfluoro-n-octanoic acid (PFOA, C_8), perfluorooctane sulfonic acid (PFOS, C_<8>) and 1H, 1H-pentadecafluoro-n-octanol (PFOL, C_8)] to induce liver microsomal carboxylesterase RL4 in male rats were studied by evaluating changes in the RL4 content by immunoblot analysis with a specific antibody. The administration of PFOA, PFOS and PFOL markedly increase the content of carboxylesterase RL4. On the other hand, PFDA decreases PNPA, BUTA, and ISOC hydrolase activity, and slightly increases the carboxylesterase RL4 content.
- 公益社団法人日本薬学会の論文
- 1996-05-15
著者
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Derbel Maher
Laboratory Of Biochemical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Chiba Unive
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Hosokawa Masakiyo
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Satoh Tetsuo
Laboratory Of Biochemical Pharmacology And Biotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Hosokawa Masakiyo
Laboratory Of Biochemical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Chiba Unive
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Satoh Tetsuo
Laboratory Of Biochemical Pharmacology And Toxicology Faculty Of Pharmaceutical Sciences Chiba Unive
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Satoh Tetsuo
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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SATOH Tetsuo
Laboratory of Biochemical Pharmacology and Biotoxicology
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