ASPIRIN INHIBITION OF HYPERCALCEMIC EFFECT OF 1α-HYDROXYVITAMIN D<SUB>3</SUB> IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Interaction of calcium regulating hormone, active form of vitamin D<SUB>3</SUB>, and aspirin (ASA) was studied in rats. One alpha-hydroxyvitamin D<SUB>3</SUB> (1α-OH-D<SUB>3</SUB>) produced a hypercalcemia in parathyroidectomized, thyroparathyroidectornized and thyroparathyroidectomized nephrectomized rats. The effect of 1α-OH-D<SUB>3</SUB> was inhibited by treatment with 200, 50 and 20 mg/kg p.o. of ASA. ASA did not stimulate the gut absorption of calcium in vitamin D deficient rats. These data suggest that ASA acts by inhibiting 1α-OH-D<SUB>3</SUB> induced bone resorption. This is the first report demonstrating the inhibitory effect of ASA on bone resorption as induced by 1α-OH-D<SUB>3</SUB>, although partial inhibition of bone resorption <I>in vitro</I> has been reported.
- 社団法人 日本薬理学会の論文
著者
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Hashimoto Yoshinobu
Teijin Institute For Biomedical Research
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Ueno Koichi
Laboratory Of Biochemical Pharmacology And Biotoxicology Department Of Drug Evaluation And Toxicolog
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Ohnuma Norio
Teijin Institute For Bio-medical Research
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KUROZUMI SEIJI
Teijin Institute for Bio-medical Research
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KAWASHIMA Hiroyuki
Hormone Research Laboratory, Department of Pathology, University of Miami, School of Medicine, Miami
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ORIMO Hajime
Teijin Institute for Bio-Medical Research
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HASHIMOTO Yoshinobu
Teijin Institute for Bio-Medical Research
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UENO Koichi
Laboratory of Biochemical Pharmacology and Biotoxicology
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