Sex Differences in PPARγ Expressions in Rat Adipose Tissues(Biopharmacy)
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概要
- 論文の詳細を見る
Clinical studies had suggested that there were sex differences in pharmacological and side effects of pioglitazone. However, there are few studies on the sex differences of peroxisome proliferator-activated receptor (PPAR) γ expressions in rat adipose tissues. We investigated the sex differences in peroxisome proliferator-activated receptor (PPAR) γ expressions in rat adipose tissues. Subcutaneous abdominal adipose tissues and perigonadal adipose tissues were obtained from male and female Wistar rats (12 weeks of age). Expressions of PPARγ protein were determined by Western blot analysis with anti-PPARγ antibody. Vaginal smear check was performed in female rats. We obtained adipose tissues from females, according to the different phases of the estrous cycle. Both PPARγl and γ2 subtypes were expressed in subcutaneous adipose tissues. Expressions of PPARγ2 in subcutaneous adipose tissues were significantly higher in males than in females. On the other hand, expressions of PPARγ2 in perigonadal adipose tissues were significantly higher in females than in males. Expressions of PPARγ2 in perigonadal adipose tissues in females significantly decreased during diestrus. It can be suggested that the sex hormones might affect the expressions of PPARγ2 in adipose tissues.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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UENO Koichi
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, C
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FUKINO Katsumi
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Fukino Katsumi
Lab. Of Clinical Pharmacology Fac. Of Pharmacy Chiba Inst. Of Sci.
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Fukino Katsumi
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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NEGISHI Etsuko
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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KADOWAKI Kyoko
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Kadowaki Kyoko
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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Ueno Koichi
Department Of Geriatric Pharmacology & Therapeutics Graduate School Of Pharmaceutical Sciences C
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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Kadowaki Kyoko
Department of Chemistry, Faculty of Education, Kanazawa University
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