METHYLENETETRAHYDROFOLATE REDUCTASE AND REDUCED FOLATE CARRIER-1 GENOTYPES AND METHOTREXATE SERUM CONCENTRATIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the genotypes of methylenetetrahydrofolate reductase (MTHFR) and reduced folate carrier-1 (RFC-1), and the serum concentrations of methotrexate (MTX) in 100 outpatients with rheumatoid arthritis (RA). Frequencies of MTHFR C677T and A1298C were similar to those reported in Japanese RA patients, while frequencies of RFC-1 G80A genotypes differed from those reported in RA patients in the United States. No correlations were found between these genotypes and serum MTX levels.
- 日本トキシコロジー学会の論文
- 2007-10-15
著者
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Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
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FUKINO Katsumi
Department of Geriatric Pharmacology & Therapeutics, Graduate School of Pharmaceutical Sciences, Chi
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Fukino Katsumi
Lab. Of Clinical Pharmacology Fac. Of Pharmacy Chiba Inst. Of Sci.
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Fukino Katsumi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences:lab
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Ueno Koichi
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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Ueno Koichi
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences
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Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
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KAWASHIMA Tomoe
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences
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Kawashima Tomoe
Department Of Geriatric Pharmacology And Therapeutics Graduate School Of Pharmaceutical Sciences
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Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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UENO Koichi
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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