EFFECTS OF ANGIOTENSIN II ON THE MEDULLARY NEURONS AND THEIR SENSITIVITY TO ACETYLCHOLINE AND CATECHOLAMINES
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概要
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In order to elucidate the mechanism of the central hypertensive action of angiotensin II (AT<SUB>II</SUB>), the effects of AT<SUB>II</SUB> on the medullary neurons of rabbits were studied by the technique of electrophoretic application. AT<SUB>II</SUB> gave rise to excitatory effect on some neurons of medulla and this effect was antagonized by a specific AT<SUB>II</SUB> antagonist, 1-sarcosine-8-alanine-AT<SUB>II</SUB>. The AT<SUB>II</SUB> sensitive medullary neurons showed no specific response to acetylcholine, norepinephrine or isoproterenol, but there was a significant increase in the excitatory response to norepinephrine in comparison with the AT<SUB>II</SUB> non-sensitive neurons. The excitatory effect of AT<SUB>II</SUB> was not blocked by atropine, phentolamine and propranolol. The AT<SUB>II</SUB> sensitive neurons in the medulla apparently do not have a topograhically or functionally characteristic distribution related to the central vasomotor control mechanisms. The neurons in the area postrema did not respond to electrophoretically applied AT<SUB>II</SUB>, while microinjection of AT<SUB>II</SUB> in this region produced remarkable hypertensive responses. These results suggest that the mechanism of the central hypertensive action of AT<SUB>II</SUB> administered into the vertebral artery is primarily mediated by the chemoreception of the area postrema. The mechanism of central cardiovascular effect of AT<SUB>II</SUB> and of the effects of acetylcholine and catecholamines on the medullary neurons are discussed.
- 社団法人 日本薬理学会の論文
著者
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Suzuki Masahiko
Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University
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SUZUKI Masami
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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Suga Toshio
Department Of Geophysics Graduate School Of Science Tohoku University
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Suzuki Masami
Department Of Metallurgy
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Suzuki Masahiko
Department Of Orthopedic Surgery Graduate School Of Medicine Chiba University
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Suzuki Masami
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
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Suzuki Masahiko
Department Of Neurology Jikei University School Of Medicine
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Suzuki Masahiko
Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo
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SUGA Toshio
Department of Pharmacology, Saitama Medical School
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Suzuki Masahiko
Department of Pharmacology, Saitama Medical School
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SUZUKI Masami
Department of Pharmacology, Saitama Medical School
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SUZUKI Masami
Department of Agricultural Chemistry, Gifu University
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Suga Toshio
Department of Astronomy and Geophysics, Faculty of Science, Tohoku University
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