Pramipexole Reduces the Prevalence of Fatigue in Patients with Parkinsons Disease
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概要
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Objective The aim of this multicenter cross-sectional study was to assess the relation between fatigue in a large number of Japanese patients with Parkinsons disease (PD) and drugs taken to treat PD. Method We used the 16-item Parkinson Fatigue Scale (PFS-16), which was designed to assess fatigue exclusively associated with PD. Multiple logistic regression analyses were used to assess the relation between antiparkinson drugs and fatigue in PD. Results A total of 350 non-demented PD patients were enrolled. Fatigue (PFS score of ≥4) was revealed in 319 patients (91%). Pramipexole was administered to 24% of PD patients. Multiple logistic regression analysis revealed that the administration of Pramipexole was significantly related to low rates of fatigue in PD patients with Hoehn and Yahr stage <3 (p=0.011, odds ratio=5.23, 95% confidence interval; 1.47-18.63). Conclusion The reduced fatigue in PD patients was observed in taking Pramipexole.
著者
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Miyamoto Tomoyuki
Department Of Neurology Dokkyo University School Of Medicine
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Miyamoto Masayuki
Department Of Neurology Dokkyo University School Of Medicine
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Okuma Yasuyuki
Department Of Neurology Juntendo University Shizuoka Hospital
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Watanabe Yuka
Department Of Biochemical Science & Technology Faculty Of Agriculture Kagoshima University
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Takahashi Kazushi
Department Of Cardiology Teikyo University School Of Medicine
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Nogawa Shigeru
Department Of Internal Medicine Keio University School Of Medicine
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Morita Akihiko
Division Of Neurology Department Of Medicine Nihon University School Of Medicine
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Yamamoto Toshimasa
Department Of Medical Microbiology And Immunology University Of South Florida College Of Medicine
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Yoshii Fumihito
Department Of Neurology Tokai University School Of Medicine
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Hatano Taku
Department Of Agricultural Chemistry Kyoto University
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Hirata Koichi
Department Of Gastrointestinal Surgery And Oncological Surgery Sapporo Medical University School Of
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Hattori Nobutaka
Department Of Neurology Juntendo University School Of Medicine
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Kamei Satoshi
Division Of Neurology Department Of Medicine Nihon University School Of Medicine
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HASHIMOTO Shiori
Department of Neurology, Tokyo Women's Medical University
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Hashimoto Shiori
Department of Neurology, Tokyo Women's Medical University, Japan
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Utsumi Hiroya
The Third Department of Internal Medicine, Division of Neurology, Tokyo Medical University, School of Medicine, Japan
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Matsumura Miyuki
Institute of Geriatrics, Tokyo Women's Medical University, Japan
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Matsumura Miyuki
Institute of Geriatrics, Tokyo Women's Medical University, Japan
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Hattori Nobutaka
Department of Neurology, Juntendo University School of Medicine, Japan
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Miyamoto Masayuki
Department of Neurology, Dokkyo Medical University, Japan
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