Snoring is Associated with an Impaired Motor Function, Disease Severity and the Quality of Life but not with Excessive Daytime Sleepiness in Patients with Parkinson's Disease
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概要
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Objective There are conflicting results regarding the frequency and clinical significance of sleep related breathing disorders in patients with Parkinson's disease (PD). The aim of this study was to investigate the relationship between snoring and its clinical correlates in patients with PD. Methods A total of 93 PD patients and 93 controls were analyzed from a previously conducted cross-sectional study. Snoring was defined as a snoring frequency of ≥2 days/week (a score of 2 or higher on the PD Sleep Scale-2 subitem 15). Excessive daytime sleepiness (EDS) was defined as an Epworth Sleepiness Scale score of ≥10. Results Snoring was more prevalent in the patients with PD than in the controls (14.0% vs. 1.1%). The PD patients who snored exhibited greater disease severity, worse scores on the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS) and the Parkinson fatigue scale and more impaired scores in several domains of the Parkinson's Disease Questionnaire, including the domains of mobility, activities of daily living, emotional well-being, communication and bodily discomfort, when compared to those who did not snore. No between-group differences were found in EDS. A higher proportion of the UPDRS motor scores for bradykinesia was seen in the PD patients who snored compared to that observed in the PD patients who did not snore. Conclusion We found that snoring was more frequent in PD patients than in controls. Furthermore, snoring in PD patients was associated with disease severity, an impaired motor function and a decreased quality of life, although it was not associated with EDS.
著者
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Miyamoto Tomoyuki
Department Of Neurology Dokkyo University School Of Medicine
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Miyamoto Masayuki
Department Of Neurology Dokkyo University School Of Medicine
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Watanabe Yuka
Department Of Biochemical Science & Technology Faculty Of Agriculture Kagoshima University
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Suzuki Shiho
Department Of Applied Biochemistry Graduate School Of Life And Environmental Sciences Osaka Prefectu
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Kadowaki Taro
Department Of Neurology Dokkyo Medical University School Of Medicine
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Tatsumoto Muneto
Department Of Neurology And First Department Of Internal Medicine Dokkyo University School Of Medici
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Hirata Koichi
Department Of Gastrointestinal Surgery And Oncological Surgery Sapporo Medical University School Of
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Suzuki Keisuke
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Yamanashi University
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Hashimoto Kenichi
Department of Neurology, Dokkyo Medical University, Japan
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Sakuta Hideki
Department of Neurology, Dokkyo Medical University, Japan
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Numao Ayaka
Department of Neurology, Dokkyo Medical University, Japan
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Iwanami Masaoki
Department of Neurology, Dokkyo Medical University Koshigaya Hospital, Japan
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Sada Tsubasa
Department of Neurology, Dokkyo Medical University, Japan
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Suzuki Shiho
Department of Neurology, Dokkyo Medical University, Japan
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Kadowaki Taro
Department of Neurology, Dokkyo Medical University, Japan
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