Gabapentin for Kleine-Levin Syndrome
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概要
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We describe a 17-year-old girl with Kleine-Levin syndrome (KLS), in which gabapentin was effective for the prevention of attacks. 99mTc-ECD SPECT revealed hyperperfusion of the thalamus and nucleus accumbens presenting in the symptomatic period, suggesting epilepsy-like neuronal discharge from these structures. Treatment for KLS has not been established, although lithium has been used in limited cases with insignificant efficacy. Here, we report a case of recurrent hypersomnia in which gabapentin was effective for the prevention of attacks. We speculate that the recurrent hypersomnia and behaviour disturbance are related to epilepsy-like neuronal discharge from the thalamus due to dysfunction in GABAnergic receptors.
著者
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Yamamoto Toshimasa
Department Of Medical Microbiology And Immunology University Of South Florida College Of Medicine
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Araki Nobuo
Department Of Neurology Keio University School Of Medicine
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Itokawa Kaori
Department Of Neurology Saitama Medical School
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Tamura Naotoshi
Department Of Neurology Saitama Medical School
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Imabayashi Etsuko
Department Of Nuclear Medicine Comprehensive Cancer Center Saitama International Medical Center Sait
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Matsuda Hiroshi
Department Of Anatomy Osaka University Medical School
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Araki Nobuo
Department of Neurology, Saitama Medical University
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Fukui Miki
Department of Neurology, Saitama Medical University
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Ninomiya Mikiko
Department of Neurology, Saitama Medical University
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Imabayashi Etsuko
Department of Radiology, Saitama International Medical Center
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