Multi-center Randomized Control Trial of Etizolam Plus NSAID Combination for Tension-type Headache
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概要
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Objective: Benzodiazepines are commonly used for the treatment of tension-type headache (TTH), however, there are few randomized controlled trials recommending the use of these drugs in Japan. This study was undertaken to evaluate the efficacy of etizolam, a thienodiazepine derivative, in combination with a non-steroidal anti-inflammatory drug (NSAID) as an acute treatment for TTH. Methods: The study design was a multi-center randomized control trial and included 144 patients. The diagnosis of TTH was based on the criteria of the International Classification of Headache Disorders-1 and all patients were diagnosed with episodic tension-type headache (ETTH). Changes in the severity of headache and shoulder pain were graded using a Visual Analogue Scale (VAS) before and after administration of drugs. Patients were randomized into NSAID alone (NSAID, mefenamic acid, 250 mg)group and NSAID (mefenamic acid, 250 mg) plus etizolam (0.5 mg) (NSAID-ET) group prior to treatment. Results: Although both groups showed a significant drop in VAS for headache and shoulder pain (p<0.01), there was no overall significant difference between the NSAID-ET and NSAID groups. However, headache was improved significantly in female patients (p<0.05), and shoulder pain was improved in young and female patients (p<0.05, p<0.04) in the NSAID-ET group. Conclusion: This study indicates that the combination treatment of etizolam and NSAID is useful in young or female patients.
著者
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Takeshima Takao
Department Of Neurology Institute Of Neurological Sciences Tottori University Faculty Of Medicine
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Araki Nobuo
Department Of Neurology Keio University School Of Medicine
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Shibata Koichi
Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University
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Tatsumoto Muneto
Department Of Neurology And First Department Of Internal Medicine Dokkyo University School Of Medici
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Hirata Koichi
Department Of Gastrointestinal Surgery And Oncological Surgery Sapporo Medical University School Of
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SAKAI FUMIHIKO
Department of Internal Medicine, School of Medicine, Kitasato University
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Igarashi Hisaka
Department of Medicine (Neurology), Kitasato University
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Sakai Fumihiko
Department of Medicine (Neurology), Kitasato University
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