NOVEL APPROACH TO IMMUNOTHERAPY FOR EPITHELIAL CANCERS, BONE AND SOFT-TISSUE SARCOMAS
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概要
- 論文の詳細を見る
The identification of tumor antigens recognized by cytotoxic T-lymphocytes and subsequent clinical trials using peptide immunization have shown tumor regression in advanced malignant melanoma patients. However, efficacious therapies for epithelial cancers, and certainly bone and soft tissue sarcomas, seemed to have been significantly delayed. For the development of a peptide-based immunotherapy for epithelial cancer and sarcomas, we have identified novel antigens recognized by CTLs using autologous pairs of tumor cell line-CTLs, or reversed immunological approach. Recently we started the phase I clinical trials of peptide-based immunotherapy. In this review, we described the recent study to establish a peptide-based immunotherapy for epithelial cancers, bone and soft-tissue sarcomas.
- 日本癌病態治療研究会の論文
著者
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TSUKAHARA Tomohide
Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine
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Tsuruma Tetsuhiro
Department Of Surgery Sapporo Medical University
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Ikeda Hideyuki
Department Of Dermatology Dokkyo University School Of Medicine
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Sahara Hiroeki
Marine Biomedical Institute Sapporo Medical University School Of Medicine
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Nagoya Satoshi
Department Of Orthopaedic Surgery Sapporo Medical University School Of Medicine
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Wada Takuro
Department Of Orthopaedic Surgery Sapporo Medical University
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Kawaguchi Satoshi
Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama
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Hirata Koichi
Department Of Gastrointestinal Surgery And Oncological Surgery Sapporo Medical University School Of
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Yamashita Toshihiko
Department Of Oral Surgery Sapporo Medical University School Of Medicine
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Sato Noriyuki
Department Of Biological Chemistry Faculty Of Agriculture Yamaguchi University
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Sato Noriyuki
Department of Pathology, Sapporo Medical University School of Medicine
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Torigoe Toshihiko
Department of First Pathology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
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Torigoe Toshihiko
Department of Pathology, Sapporo Medical University School of Medicine
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Tsuruma Tetsuhiro
Department of Surgery, Sappon Medical University School of Medicine
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Tsukahara Tomohide
Department of Orthopedic Surgery, Sapporo Medical University School of Medicine
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Hirata Koichi
Department of Chemistry, Faculty of Science, Osaka University
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