EXPRESSION OF XANTHINE OXIDASE IN TESTICULAR CELLS
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概要
- 論文の詳細を見る
Objective : Previous studies showed that xanthine oxidase-related active oxygen generation was involved in heat stress-induced apoptosis in testicular cells. Hence, in the present study, the expressionof xanthine oxidase in experimental cryptorchidism and heat-stressed testicular cells was assessed to determine the involvement of xanthine oxidase-related active oxygen generation in heat stress-induced apoptosis in testicular cells. Methods : (1) Immunohistological examinationof xanthine oxidase was performed in a rat model of cryptorchidism. (2) mRNA expression of xanthine oxidase in cultured rat testicular cells was assessed by RT-PCR. (3) Expression of xanthine oxidase protein in cultured rat testicular cells was assessed by western blot analysis.Results : The presence of xanthine oxidase in testicular cells was confirmed by immunohistochemistry, especially after the spermatid stage. mRNA expression of xanthine oxidase in cultured testicular cells was similar with and without heat stress as determined by semiquantitative RTPCR. Expression of xanthine oxidase protein in cultured testicular cells was similar under both conditions, i.e., at 32.5˚C and at 37.0˚C, as determined by western blot analysis. Conclusions : mRNA and protein expression of xanthine oxidase was confirmed in testicular cells. Quantitative changes in xanthine oxidase expression cause by heat stress have not been clarified. These findings suggest that activate oxygen generated by xanthine oxidase is involved in apoptosis of testicular cells induced by heat stress.
- 秋田大学の論文
著者
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TANAKA Toshinobu
Department of Obstetrics and Gynecology, Akita University School of Medicine
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Kawaguchi Satoshi
Department of Vascular Surgery
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FUKUDA JUN
Department of Kinesiology, University of Illinois at Urbana-Champaign
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Tanaka Toshinobu
Department Of Obstetrics And Gynecology Akita University Graduate School Of Medicine
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Tanaka Toshinobu
Department Of Gynecology And Obstetrics Akita University School Of Medicine
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Fukuda Jun
Department Of Obstetrics And Gynecology Akita University Graduate School Of Medicine
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Kumagai Jin
Department Of Obstetrics And Gynecology Akita University Graduate School Of Medicine
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SHIMIZU Yasushi
Department of Obstetrics and Gynecology,Akita University Graduate School of Medicine
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KAWAMURA Kazuhiro
Department of Obstetrics and Gynecology,Akita University Graduate School of Medicine
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Kawaguchi Satoshi
Department Of Complex Systems School Of Systems Information Science Future University
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Shimizu Yasushi
Department Of Obstetrics And Gynecology Akita University Graduate School Of Medicine
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Kawamura Kazuhiro
Division Of Obstetrics And Gynecology Department Of Reproductive And Developmental Medicine Akita Un
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Kawamura Kazuhiro
Department Of Obstetrics And Gynecology Akita University School Of Medicine
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Kawaguchi Satoshi
Department Of Bioscience And Biotechnology Graduate School Of Natural Science And Technology Okayama
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Fukuda Jun
Department Of Gynecology And Obstetrics Akita University School Of Medicine
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Kawamura Kazuhiro
Department Of Biology Faculty Of Science Chiba University
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Shimizu Yasushi
Department Of Anatomy Tokyo Dental College
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Kawaguchi Satoshi
Department Of Obstetrics And Gynecology Akita University Graduate School Of Medicine
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Fukuda Jun
Division Of Obstetrics And Gynecology Department Of Reproductive And Development Medicine Akita Univ
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Kumagai Jin
Department of Internal Medicine, Chiba Aoba Municipal Hospital, Japan
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