Preparation of a Clonidine Ointment and its Application to Sympathetically Maintained Pain (SMP)
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概要
- 論文の詳細を見る
To treat sympathetically maintained pain (SMP), we prepared an ointment containing clonidine hydrochloride, an α adrenergic agonist, as an in-hospital preparation and observed SMP alleviation in patients treated with it. No redness or other abnormalities were observed in the ointment application area, and there was no blood pressure fall, a pharmacological effect of orally administered clonidine. Plasma clonidine concentrations after applying the ointment were 40-80pg/mL, which were sufficiently lower than those required for blood pressure control. These results suggest that clonidine ointment is safe and effective against SMP. It can be used at home and is therefore useful for improving the quality of life (QOL) of patients with chronic pain.
- 日本医療薬学会の論文
- 2007-12-10
著者
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Ikarashi Nobutomo
Department of Clinical Pharmacokinetics, School of Pharmacy and Pharmaceutical Sciences, Hoshi Unive
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Ito Kiyomi
Department of Clinical Pharmacokinetics, School of Pharmacy and Pharmaceutical Sciences, Hoshi Unive
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Sugiyama Kiyoshi
Department of Clinical Pharmacokinetics, School of Pharmacy and Pharmaceutical Sciences, Hoshi Unive
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Watanabe Yuka
Department Of Biochemical Science & Technology Faculty Of Agriculture Kagoshima University
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Shibuya Fuminori
Department of Pharmacy, Tokyo Metropolitan Police Hospital
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Nakamura Kanna
Department of Anesthesiology, Tokyo Metropolitan Police Hospital
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Motoyama Yoshimasa
Department of Anesthesiology, Tokyo Metropolitan Police Hospital
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Yamagishi Mami
Konishi Pharmacy
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Motoyama Yoshimasa
Department Of Anesthesiology Tokyo Metropolitan Police Hospital
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Ito Kiyomi
Department Of Clinical Pharmacokinetics Hoshi University
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Nakamura Kanna
Department Of Anesthesiology Tokyo Metropolitan Police Hospital
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Sugiyama Kiyoshi
Dep. Of Clinical Pharmacokinetics Hoshi Univ.
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Sugiyama Kiyoshi
Department Of Clinical Pharmacokinetics Hoshi University
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Shibuya Fuminori
Department Of Pharmacy Tokyo Metropolitan Police Hospital
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Ikarashi Nobutomo
Department of Clinical Pharmacokinetics, Hoshi University
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Ito Kiyomi
Department of Clinical Pharmacokinetics, Hoshi University
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Watanabe Yuka
Department of Clinical Pharmacokinetics, Hoshi University
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