Intravenous Immunoglobulin Therapy for Autoantibody-Positive Cerebellar Ataxia
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概要
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Objective It has been reported that autoimmune cerebellar ataxias, such as anti-glutamic acid decarboxylase (GAD)-antibody-positive cerebellar ataxia and gluten ataxia, are treatable. Here, we examined the therapeutic efficacy of intravenous immunoglobulin (IVIg) on autoantibody-positive cerebellar ataxia. Patients and Methods IVIg therapy was administered in seven autoantibody-positive cerebellar ataxia patients. Therapeutic efficacy was examined in terms of its effects on clinical symptoms and changes in brain perfusion using single photon emission computed tomography (SPECT). Results Treatment was effective in four cerebellar cortical atrophy patients (two anti-GAD antibody-positive and two anti-gliadin antibody-positive) and in one anti-thyroid antibody-positive spinocerebellar ataxia type 3 (SCA3) patient, but not in two multiple system atrophy (MSA) patients. All four IVIg effective patients who underwent SPECT showed apparent increases in cerebellar perfusion. Conclusion If cerebellar ataxia with an autoimmune mechanism is suspected and radiological findings do not reveal MSA, it is worth considering immunotherapy including IVIg.
- 社団法人 日本内科学会の論文
著者
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Taguchi Takeshi
Department Of Food Science And Technology Tokyo University Of Fisheries
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Otsuka Takao
Department Of Chemistry Faculty Of Science Kanazawa University
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Koizumi Kiyoshi
Department Of Cardiovascular Surgery Saiseikai Utsunomiya Hospital
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KOIZUMI Kiyoshi
Department of Radiology, Tokyo Medical University Hachioji Medical Center
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Mitoma Hiroshi
Postgraduate Clinical Residents' Center, Tokyo Medical University
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Nanri Kazunori
Department of Neurology, Tokyo Medical University Hachioji Medical Center
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Okita Mitsunori
Department of Neurology, Tokyo Medical University Hachioji Medical Center
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Takeguchi Masafumi
Department of Neurology, Tokyo Medical University Hachioji Medical Center
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Ishiko Tomoko
Department of Neurology, Tokyo Medical University Hachioji Medical Center
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Saito Hirohiko
Department of Neurology, Tokyo Medical University Hachioji Medical Center
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Taguchi Takeshi
Department of Neurology, Tokyo Medical University Hachioji Medical Center
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