Repeated Non-enhancing Tumefactive Lesions in a Patient with a Neuromyelitis Optica Spectrum Disorder
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概要
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A 51-year-old woman had developed fever and consciousness disturbance at 47 years of age. Brain magnetic resonance imaging (MRI) revealed acute disseminating encephalomyelitis (ADEM)-like lesions without gadolinium enhancement (GDE). One year later, she had an episode of bilateral optic neuritis and cerebellar ataxia. Speech deficit and right hand weakness occurred at the age of 51 years. Neurological examination showed motor aphasia, finger agnosia, right-left disorientation, and right hand paresis. Neuromyelitis optica (NMO)-IgG was seropositive. Cerebrospinal fluid examination showed negative results for myelin basic protein and oligoclonal IgG band. The IgG index was normal. Brain MRI revealed a tumefactive lesion in the left temporo-parietal region and conglomerate ovoid lesions in the pericallosal regions. No GDE was found in the brain lesions. Visual evoked potential test showed bilateral prolongation of P100 latencies. She was treated twice with methylprednisolone pulse therapy followed by oral prednisolone, but the motor aphasia did not respond to steroid treatment. She had no prior history of myelitis and was diagnosed as NMO spectrum disorder (NMOSD). Similar to previous studies of NMO-IgG seropositive extensive brain lesions, this patient with NMOSD indicated no GDE in tumefactive lesions at two episodes of encephalopathy. Compared to multiple sclerosis (MS), a high frequency of non-enhancing tumefactive lesions is reported in patients with NMO or NMOSD. The absence of GDE in tumefactive lesions could help to differentiate between NMO and MS.
著者
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Takazawa Takanori
Department of Neurology, Toho University Omori Medical Center
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Ito Hirono
Department of Neurology, Toho University Omori Medical Center
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Kano Osamu
Department of Neurology, Toho University Omori Medical Center
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Kawabe Kiyokazu
Department of Neurology, Toho University Omori Medical Center
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Iwasaki Yasuo
Department Of Neurology Toho University Ohmori Hospital
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IKEDA Ken
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine
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Hirayama Takehisa
Department of Neurology, Toho University Omori Medical Center, Japan
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Yoshii Yasuhiro
Department of Neurology, Toho University Omori Medical Center, Japan
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Hirayama Takehisa
Department of Neurology, Toho University Omori Medical Center
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Sekine Tokinori
Department of Neurology, Toho University Omori Medical Center
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Takazawa Takanori
Department of Neurology, Toho University Omori Medical Center, Japan
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Hidaka Takanobu
Department of Neurology, Makita General Hospital, Japan
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Yoshii Yasuhiro
Department of Neurology, Toho University Omori Medical Center
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Kano Osamu
Department of Neurology, Toho University Omori Medical Center, Japan
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Kano Osamu
Department of Neurology, The Methodist Neurological Institute, Weill Cornell Medical College
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Kawabe Kiyokazu
Department of Neurology, Oomori Hospital, Toho University
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Ito Hirono
Department of Neurology, Toho University Omori Medical Center, Japan
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Sekine Tokinori
Department of Neurology, Toho University Omori Medical Center, Japan
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