Ophthalmoplegia and Flaccid Paraplegia in a Patient with Anti-NMDA Receptor Encephalitis: A Case Report and Literature Review
スポンサーリンク
概要
- 論文の詳細を見る
We herein report the case of a 26-year-old woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis presenting with ophthalmoplegia and flaccid paraplegia. She developed disorientation and hallucination after fever and vomiting. Hypothermia, hypoventilation, hypertension, paralytic ileus and hyponatremia were present. Neurological examination showed mild consciousness disturbance and bilateral ophthalmoplegia on admission, flaccid paraplegia with leg areflexia on Day 4. Anti-NMDAR antibodies were detected in the serum and cerebrospinal fluid samples. Motor nerve conduction velocity was decreased in the tibial and peroneal nerves. F-wave amplitudes were reduced in the tibial nerve. MRI disclosed lesions in the callosal splenium, hippocampus and cerebral subarachnoid regions. In addition to various encephalitic symptoms, physicians should pay more attention to peripheral nerve damage in patients with anti-NMDAR encephalitis.
- 社団法人 日本内科学会の論文
著者
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Takazawa Takanori
Department of Neurology, Toho University Omori Medical Center
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Kano Osamu
Department of Neurology, Toho University Omori Medical Center
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Kawabe Kiyokazu
Department of Neurology, Toho University Omori Medical Center
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Ishikawa Yuichi
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Iwasaki Yasuo
Department Of Neurology Toho University Ohmori Hospital
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Takahashi Yukitoshi
Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
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IKEDA Ken
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine
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Murata Kiyoko
Department of Neurology, Toho University Omori Medical Center
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Hirayama Takehisa
Department of Neurology, Toho University Omori Medical Center
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Iwasaki Yasuo
Department of Neurology, Toho University Omori Medical Center, Japan
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Yanagihashi Masaru
Department of Neurology, Toho University Omori Medical Center, Japan
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Kano Osamu
Department of Neurology, The Methodist Neurological Institute, Weill Cornell Medical College
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Kawabe Kiyokazu
Department of Neurology, Toho University Omori Medical Center, Japan
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Kawabe Kiyokazu
Department of Neurology, Oomori Hospital, Toho University
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Takahashi Yukitoshi
Department of Pediatrics, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
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