Clinicoradiological Profile and Serum Lipid Levels of Intracerebral Hemorrhage in Prior Statin Users
スポンサーリンク
概要
- 論文の詳細を見る
Objective We aimed to evaluate whether serum lipid levels can influence the clinicoradiological recovery of intracerebral hemorrhage (ICH) in prior statin users. Patients and Methods Medical records were reviewed retrospectively in 381 ICH patients (253 men and 128 women). Cardiovascular disease (CVD) risk factors, blood pressure at admission and the first in-hospital day, admission and 30-day scores of National Institute Health Stroke Scale (NIHSS) and modified Rankin scale (mRS), hematoma volume (HV), serum lipid levels were compared between prior statin users and non-users. Results Statins were pretreated in 56 patients (31 men and 25 women). Statin users were older age, and had higher frequencies of dyslipidemia, diabetes mellitus, atrial fibrillation, prior stroke history and large HV compared to non-users. Serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly decreased in the statin group compared to the non-statin group. There were no statistical differences in the other CVD risk factors, functional scores and other serum lipid levels between the two groups. HV was correlated inversely with serum levels of TC and LDL-C in both groups. Multiple logistic regression analysis showed that serum TC levels ≤150 mg/dL were associated with statin use [Odds ratio (OR)=5.5, 95% confidence interval (CI)=1.55-19.58], worsening of NIHSS score (OR=1.4, 95% CI=1.21-1.63) and HV (OR=1.1, 95% CI=1.07-1.13) in ICH patients. A significant association was found between worsening of NIHSS score (OR=2.0, 95% CI=1.32-3.12) and worsening of mRS score (OR=3.3, 95% CI=1.33-8.00), HV (OR=1.3, 95% CI=1.01-1.76), and serum TC levels ≤150 mg/dL in statin users. Conclusion Prior statin users with serum TC levels ≤150 mg/dL had worsening of outcome and HV. Excessive lowering of serum TC levels due to statin pretreatment may cause unfavorable clinicoradiological recovery of ICH. Physicians should monitor serum lipid levels carefully in statin users.
著者
-
Miura Ken
Department Of Medical Zoology School Of Medicine
-
Nakamura Yoshikazu
Department Of Basic Medical Sciences Institute Of Medical Science University Of Tokyo
-
IKEDA Ken
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine
-
Yoshii Yasuhiro
Department of Neurology, Toho University Omori Medical Center, Japan
-
Yoshii Yasuhiro
Department of Neurology, Toho University Omori Medical Center
関連論文
- A Distinct Phenotype of Leg Hyperreflexia in a Japanese Family with Gerstmann-Sträussler-Scheinker Syndrome (P102L)
- 2P-119 ヒトIgGに結合するRNAアプタマー複合体の立体構造(核酸・相互作用,複合体,第46回日本生物物理学会年会)
- Association Between Health-Related Knowledge and the Awareness of Blood Pressure Readings
- 川崎病不全型の冠動脈障害出現頻度
- A genomewide linkage analysis of Kawasaki disease : evidence for linkage to chromosome 12
- Transient Restricted Diffusion of Whole Corpus Callosum and Symmetrical White Matter in Epilepsy
- VITELLOGENIN SYNTHESIS AND EFFECTS OF JUVENLE HORMONE IN THE TICK ORNITHODOROS PARKERI : Biochemistry
- Revision of diagnostic guidelines for Kawasaki disease : the 5th revised edition
- Scopolamine-induced Migraine Like Headache
- Familial Amyotrophic Lateral Sclerosis with a Novel G85S Mutation of Superoxide Dismutase 1 Gene: Clinical Features of Lower Motor Neuron Disease
- Macrocystic serous cystadenoma of the pancreas : importance of co-existent tiny cysts depicted by EUS
- Repeated Non-enhancing Tumefactive Lesions in a Patient with a Neuromyelitis Optica Spectrum Disorder
- 新生児慢性肺疾患発症への Ureaplasma の関与
- Thermally Stimulated Exoelectron Emission from Austenitic and Ferritic Stainless Steels : Exoemission Mechanism and Related Phenomena
- Genotyping of Pneumocystis carinii f.sp.hominis Isolates in Japan Based on Nucleotide Sequence Variations in lnternal Transcribed Spacer Regions of rRNA Genes
- Application of the relaxation technique in general hospital psychiatry
- Cloning of mRNA Sequences for Two Antibacterial Peptides in a Hemipteran Insect, Riptortus clavatus
- A Case of Trigeminal Neuralgia and Neurogenic Hypertension Due to Megadolichobasilar Artery Anomaly
- Serial Measurement of Brachial-ankle Pulse Wave Velocity after Intramuscularly Administration of Scopolamine Butylbromide
- Incidence and Clinical Hallmark of Brain Tumors and Cerebral Aneurysms on Repeated Brain Check-up
- The relation between trace elements and amyotrophic lateral sclerosis (特集:微量元素と疾患)
- Clinicoradiological Profile and Serum Lipid Levels of Intracerebral Hemorrhage in Prior Statin Users
- Rheumatoid Leptomeningitis: Radiological Alteration of Cerebral Hypoperfusion and Subarachnoid Lesions
- A Case of Gliomatosis Cerebri Mimicking Limbic Encephalitis: Malignant Transformation to Glioblastoma
- Influenza-associated Monophasic Neuromyelitis Optica
- Effect of Ag Content on Properties of Sn-Ag Binary Alloy Solder
- Magneto-Optical Properties of Cd_Mn_xTe Multiple Quantum Wells Prepared by Ionized-Cluster Beam Technique
- Magneto-Optical Properties of Cd_Mn_xTe with High Mn Concentration
- Thermally Stimulated Exoelectron Emission from BaTiO_3 Ceramics
- Effect of Initial Microstructure on Superplasticity in Ultrafine Grained 18Cr-9Ni Stainless Steel
- Structural and Functional Studies on Biliverdin-associated Cyanoprotein from the Bean Bug, Riptortus clavatus
- cDNA CLONING AND ANALYSES OF MOSQUITO AhR AND ARNT ISOFORMS(Biochemistry)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Mapping the Interactions of Translational Factors with the Ribosome
- Molecular Microbiology of Pneumocystis carinii
- Cross-Talk between RNA and Prions
- How Can the National Burden of Parkinson's Disease Comorbidity and Mortality Be Estimated for the Japanese Population?
- Sudden Deafness and Facial Diplegia in Guillain-Barré Syndrome: Radiological Depiction of Facial and Acoustic Nerve Lesions
- Rapid Development of Central Pontine Myelinolysis after Recovery from Wernicke Encephalopathy: A Non-alcoholic Case without Hyponatremia
- A Case of Posterior Spinal Artery Syndrome in the Cervical Cord: A Review of the Clinicoradiological Literature
- Relationships between Disease Progression and Serum Levels of Lipid, Urate, Creatinine and Ferritin in Japanese Patients with Amyotrophic Lateral Sclerosis: A Cross-Sectional Study
- Effect of Short Duration-Adaptive Servo-Ventilation Therapy on Cardiac Function in Patients With Heart Failure
- Wegener Granulomatosis-associated Optic Perineural Hypertrophy and Optic Neuropathy
- Culmen Infarct Triggers Isolated Body Backpulsion
- Ophthalmoplegia and Flaccid Paraplegia in a Patient with Anti-NMDA Receptor Encephalitis: A Case Report and Literature Review
- A Case of Inferolateral Oculomotor Fascicular Infarction: A Review of the Clinicoradiological Literature
- OBSERVATION ON THE STRUCTURAL CHANGE IN GLYCERINATED MUSCLE FIBERS PRODUCED BY ALKALINE EARTH METAL PRECIPITANTS