A Clinicopathological Study of Resected Small-Sized Squamous Cell Carcinomas of the Peripheral Lung: Prognostic Significance of Serum Carcinoembryonic Antigen Levels
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概要
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Purpose: The purpose of this retrospective study was to evaluate common clinicopathological factors and clarify the prognostic factors of small-sized peripheral-lung squamous cell carcinomas.Methods: We retrospectively reviewed 71 patients with peripheral squamous cell carcinoma ≤3 cm in diameter, who were surgically treated between January 1989 and December 2010. Patients undergoing partial lung resection without lymph node dissection were excluded. The median follow-up for living patients was 63 months.Results: The overall 3- and 5-year survival rates were 83.9% and 74.7%, respectively.Although the ROC curve of serum carcinoembryonic antigen (CEA) levels showed marginally significance (P = 0.050), multivariate analyses revealed that age (P = 0.043), lymph node metastasis (P = 0.004), and preoperative serum carcinoembryonic antigen (CEA) level (P = 0.037) were independent prognostic factors. For pathologic N0 patients, there was a significant difference for recurrence-free survival based on CEA levels: patients with normal CEA levels (n = 40), 5-year-recurrence-free rate = 93.5%;elevated CEA (n = 14), 5-year-recurrence-free rate = 72.7% (P = 0.0160). The distribution of tumor cells immunoreactive for CEA was significantly associated with serum CEA levels (P = 0.033).Conclusion: Age, lymph node metastasis, and serum CEA level are independent prognostic factors for small-sized peripheral-lung squamous cell carcinoma.
著者
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Ishikawa Yuichi
Department Of Applied Chemistry Faculty Of Engineering Oita University
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Nakagawa Ken
Department Of Chest Surgery Cancer Institute Hospital
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Mun Mingyon
Department Of Thoracic Surgery Toranomon Hospital
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Sakao Yukinori
Deparment Of Pathology Institute Of Basic Medical Science University Of Tsukuba
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Masuda Munetaka
Department Of Cardiovascular Surgery Kyushu University Hospital
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Okumura Sakae
Department Of Thoracic Surgical Oncology The Cancer Institute Hospital Japanese Foundation For Cancer Research
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Sakao Yukinori
Department of Thoracic Surgical Oncology, Japanese Foun dation for Cancer Research, Cancer Institute Hospital, Tokyo, Japan
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Nagashima Takuya
Department of Thoracic Surgical Oncology, Japanese Foun dation for Cancer Research, Cancer Institute Hospital, Tokyo, Japan
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Masuda Munetaka
Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan
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Nakagawa Ken
Department of Thoracic Surgical Oncology, Japanese Foun dation for Cancer Research, Cancer Institute Hospital, Tokyo, Japan
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