Effects of Cilazapril on Exercise Tolerance in the Chronic Phase of Acute Myocardial Infarction
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概要
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The present study was conducted to investigate the effects of cilazapril on exercise tolerance and the hormone kinetics of catecholamines, the renin-angiotensin-aldosterone system and alpha-atrial natriuretic peptide (ANP) in patients in the chronic phase of acute myocardial infarction (AMI). The subjects consisted of 19 cases of AMI. Cardiopulmonary exercise testing was performed 1 month after the onset of AMI, and patients were randomly assigned to either a group treated with 1 mg/day of cilazapril (9 cases) and or an untreated group (10 cases). After the completion of 2 months of exercise training at the anaerobic threshold (AT), blood samples were taken during a cardiopulmonary exercise test and various hormones were measured. In comparing the parameters of exercise tolerance before and after the completion of exercise training there were no significant differences between the 2 groups with respect to oxygen uptake, oxygen pulse, or exercise time at AT or at peak exercise. With regard to temporal changes in exercise tolerance oxygen uptake, oxygen pulse and exercise time all tended to increase in both groups. With ragard to hormone kinetics, the alpha-ANP concentration at peak exercise was significantly lower, and the noradrenaline secretions also tended to be lower, in the cilazapril-treated group, even though the peak exercise time was similar in both groups. These results may be support the hypothesis that cilazapril mitigates the left ventricular load during exercise therapy in patients in the chronic phase of AMI.
- 社団法人日本循環器学会の論文
- 1996-10-20
著者
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Murayama Masahiro
Division Of Cardiology St. Marianna University School Of Medicine
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Murayama Masahiro
The Second Department Of Internal Medicine University Of Tokyo
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Nakayama Masaru
Third Department Of Internal Medicine Showa University School Of Medicine
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Iinuma Hiroyuki
鹿児島大学 大学院医歯学総合研究科循環器･呼吸器･代謝内科学
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Nakayama Masaru
Division Of Cardiology The Cardiovascular Institute
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Yamamoto Akiko
Division of Cardiology, Department of Internal Medicine, St Marianna University School of Medicine
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Yokoyama Yasuhiro
Division of Cardiology, Department of Internal Medicine, St Marianna University School of Medicine
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Tanabe Kazuhiko
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Yamamoto Akiko
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Suzuki Noriyuki
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Nakayama Masaru
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Yokoyama Yasuhiro
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Osada Naohiko
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Itoh Haruki
The Second Department of Internal Medicine, St Marianna University School of Medicine
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Yamada Sumio
Department of Rehabilitation of Medicine
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Sakakibara Masayoshi
The Second Department of Internal Medicine, St.Marianna University School of Medicine
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Yamasaki Hiroshi
The Second Department of Internal Medicine, St.Marianna University School of Medicine
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Yokoyama Yasuhiro
Division Of Cardiology Department Of Internal Medicine St Marianna University School Of Medicine
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Nakayama Masaru
Department Of Cardiology Sakakibara Heart Institute
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Tanabe Kazuhiko
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Yamada Sumio
Institute Of Medical Sciences University Of Nagoya
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Yamamoto Akiko
Division Of Cardiology Department Of Internal Medicine St Marianna University School Of Medicine
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Yamamoto Akiko
The Second Department Of Internal Medicine And The Department Of Hygiene Gunma University School Of
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SAKAKIBARA Masayoshi
Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine
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Murayama Masahiro
Division Of Cardiology Department Of Internal Medicine St Marianna University School Of Medicine
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Yamasaki Hiroshi
Department Of Rehabilitation Medicine St Marianna University School Of Medicine
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Yamamura Yukio
The Department Of Public Health St. Marianna University School Of Medicine
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Yamuura Yukio
Department Of Public Health St. Marianna University School Of Medicine
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Murayama Masahiro
The Second Department Of Internal Medicine Faculty Of Medicine
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Yamada Sumio
Department Of Physical Therapy Nagoya University School Of Health Sciences
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Sakakibara Masayoshi
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Murayama Masahiro
The Second Department Of Internal Medicine St. Marianna University School Of Medecine
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Murayama Masahior
The 2nd Department Of Internal Medicine St. Marianna University
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Sakakibara Masayoshi
St Marianna University School Of Medicine
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