Complexation of Tocotrienol with γ-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats
スポンサーリンク
概要
- 論文の詳細を見る
To determine the bioavailability of tocotrienol complex with γ-cyclodextrin, the effects of tocotrienol/γ-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with γ-cyclodextrin, or tocotrienol/γ-cyclodextrin complex. At 3 h after administration, the plasma γ-tocotrienol concentration of the rats administered tocotrienol/γ-cyclodextrin complex was higher than that of the rats administered tocotrienol and γ-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with γ-cyclodextrin, or tocotrienol/γ-cyclodextrin complex. The plasma γ-tocotrienol concentration of the Triton-treated rats administered tocotrienol/γ-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with γ-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.
著者
-
Ichikawa Tomio
Department Of Food Science And Nutrition School Of Human Life And Environmental Sciences Mukogawa Wo
-
YANO Tomohiro
Project for Complementary Factors, National Institute of Health and Nutrition
-
IKEDA Saiko
Department of Anatomy, jaunted University Scool of Medicine
-
UCHIDA Tomono
Department of Nutritional Sciences, Nagoya University of Arts and Sciences
-
Nakata Daisuke
Cyclochem Co. Ltd. Kibc
-
Ikeda Saiko
Department Of Nutritional Sciences Nagoya University Of Arts And Sciences
-
WATANABE Takashi
Oryza Oil & Fat Chemical Co., Ltd.
-
UEKAJI Yukiko
CycloChem Co., Ltd., KIBC
-
TERAO Keiji
CycloChem Co., Ltd., KIBC
関連論文
- Enhanced Effect of Connexin 43 on Cisplatin-Induced Cytotoxicity in Mesothelioma Cells
- Complexation of Tocotrienol with γ-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats
- Effects of Gum Arabic and Pectin on the Emulsification, the Lipase Reaction, and the Plasma Cholesterol Level in Rats(Food & Nutrition)
- Connexin 32 as an Anti-invasive and Anti-metastatic Gene in Renal Cell Carcinoma
- Metabolism of ^C-Isomaltooligosaccharides in Healthy Men
- Molecular Characterization of a Novel Gamma-Glutamyl Transpeptidase Homologue Found in Rat Brain
- Inhibition of Expression of Ornithine Decarboxylase by c-myc Antisense Oligonucleotide at the Promotion Stage of Lung Tumorigenesis in Mice
- Studies of Phosphoryl Oligosaccharides Prepared from Potato Starch〔含 質疑応答〕 (糖質関連酵素化学シンポジウム)
- A Comparative Study of Glioma Cell Lines for p15, p16, p53 and p21 Gene Alterations Gene
- Intracranial Germ Cell Tumors: Detection of p53 Gene Mutations by Single-strand Conformation Polymorphism Analysis
- Inhibitory Effect of Phosphorylated Oligosaccharides Prepared from Potato Starch on the Formation of Calcium Phosphate
- ACTIVE OXYGEN GENERATION BY ALVEOLAR MACROPHAGE IN MICE TREATED WITH CARCINOGEN AND PROMOTER
- Cell surface-associated extracellular distributi9on of a neural proteoglycan, 6B4 proteoglycan/phosphacan, in the olfactory epithelium, olfactory nerve, and cells migrating along the olfactory nerve in chick embryos
- Rare-type Mutations of MMAC1 Tumor Suppressor Gene in Human Glioma Cell Lines and Their Tumors of Origin
- Primary Malignant Lymphoma of the Brain: Demonstration of Frequent p16 and p15 Gene Deletions
- Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats
- Dietary Sesame Lignans Decrease Lipid Peroxidation in Rats Fed Docosahexaenoic Acid
- Complexation of Tocotrienol with γ-Cyclodextrin Enhances Intestinal Absorption of Tocotrienol in Rats
- Hydroxymatairesinol and Sesaminol Act Differently on Tocopherol Concentrations in Rats
- Dietary Sesame Seed Decreases Urinary Excretion of α- and γ-Tocopherol Metabolites in Rats
- Dietary Sesame Seeds Elevate α-Tocopherol Concentration in Rat Brain
- Tissue Distribution of Vitamin E Metabolites in Rats after Oral Administration of Tocopherol or Tocotrienol
- Simultaneous Determination of Hydrogen, Methane and Carbon Dioxide of Breath Using Gas-Solid Chromatography.